Method for detecting nucleic acid amplification using self-quenching fluorescence probe
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United States of America Patent
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Jul 23, 1996
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app pub date -
Nov 16, 1994
filing date -
Nov 16, 1994
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Abstract
A method is provided for monitoring the progress of nucleic acid amplifications that rely on a nucleic acid polymerase having 5'.fwdarw.3' exonuclease activity. An important feature of the method is providing an oligonucleotide probe having a reporter molecule and a quencher molecule at either end such that the quencher molecule substantially quenches any fluorescence from the reporter whenever the oligonucleotide probe is in a single stranded state and such that the reporter is substantially unquenched whenever the oligonucleotide probe is in a double stranded state hybridized to a target polynucleotide.
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