US Patent No: 5,539,082

Number of patents in Portfolio can not be more than 2000

Peptide nucleic acids

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Abstract

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A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

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First Claim

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Patent Owner(s)

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International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berg, Rolf H Rungsted Kyst, DK 14 505
Buchardt, Ole 3500 V.ae butted.rlose, DK 32 573
Egholm, Michael 2000 Frederiksberg, DK 70 1534
Nielsen, Peter E Hjortevanget 509, DK 2980 Koddedal, DK 29 531

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MONSANTO COMPANY (1)
5,134,066 Improved probes using nucleosides containing 3-dezauracil analogs 150 1989
 
NEU-GENE DEVELOPMENT GROUP, A CORP. OF OR (1)
5,142,047 Uncharged polynucleotide-binding polymers 98 1987

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
ISIS PHARMACEUTICALS, INC. (68)
6,077,833 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 17 1996
6,339,066 Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate .beta.I, .beta.II, .gamma., .delta., .EPSILON., .zeta. and .eta. isoforms of human protein kinase C 1 1997
6,015,887 Chiral peptide nucleic acids and methods for preparing same 9 1997
5,985,558 Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos 33 1997
6,893,815 Nucleobase heterocyclic combinatorialization 0 1997
5,877,309 Antisense oligonucleotides against JNK 57 1997
7,321,828 System of components for preparing oligonucleotides 49 1998
6,117,847 Oligonucleotides for enhanced modulation of protein kinase C expression 3 1998
6,528,631 Oligonucleotide-folate conjugates 30 1998
6,300,319 Targeted oligonucleotide conjugates 25 1998
6,887,906 Compositions and methods for the delivery of oligonucleotides via the alimentary canal 34 1998
6,277,603 PNA-DNA-PNA chimeric macromolecules 3 1998
6,221,850 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 6 1998
6,175,004 Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine 4 1998
6,225,293 Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations 0 1998
6,069,243 Process for oligonucleotide synthesis 14 1998
6,492,111 In situ binary synthesis of biologically effective molecules 0 1998
6,300,320 Modulation of c-jun using inhibitors of protein kinase C 0 1999
6,399,765 Methods for removing dimethoxytrityl groups from oligonucleotides 3 1999
6,335,434 Nucleosidic and non-nucleosidic folate conjugates 61 1999
6,133,246 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 82 1999
8,153,602 Composition and methods for the pulmonary delivery of nucleic acids 0 1999
6,841,539 Compositions and methods for topical delivery of oligonucleotides 14 1999
6,319,906 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 12 1999
6,656,730 Oligonucleotides conjugated to protein-binding drugs 27 1999
6,613,873 Peptide nucleic acids having 2,6-diaminopurine nucleobases 1 1999
6,593,466 Guanidinium functionalized nucleotides and precursors thereof 9 1999
6,312,900 Antisense oligonucleotide compositions and methods for the modulation of activating protein 1 3 1999
6,753,423 Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals 5 2000
6,762,169 Ligand-conjugated oligomeric compounds 10 2000
6,534,639 Guanidinium functionalized oligonucleotides and method/synthesis 18 2000
6,809,193 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 15 2001
6,525,031 Targeted Oligonucleotide conjugates 15 2001
6,861,514 Nucleosidic and non-nucleosidic folate conjugates 4 2001
6,537,973 Oligonucleotide inhibition of protein kinase C 6 2001
6,747,014 Compositions and methods for non-parenteral delivery of oligonucleotides 28 2001
6,921,812 Methods of modulating pharmacokinetics of oligonucleotides 2 2002
7,695,902 Oligoribonucleotides and ribonucleases for cleaving RNA 11 2002
6,794,502 Methods for removing dimethoxytrityl groups from oligonucleotides 0 2002
7,038,037 Method for sequential support-bound synthesis of conjugated oligomeric compounds 0 2002
6,914,148 Guanidinium functionalized intermediates 0 2002
6,660,720 Targeted oligonucleotide conjugates 0 2002
7,002,006 Protection of nucleosides 1 2003
7,169,916 Chloral-free DCA in oligonucleotide synthesis 7 2003
7,235,653 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 4 2003
8,604,183 Compositions comprising alternating 2′-modified nucleosides for use in gene modulation 0 2003
7,812,149 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations 2 2003
8,394,947 Positionally modified siRNA constructs 0 2004
7,960,355 Compositions and methods for the modulation of the expression of B7 protein 0 2004
7,276,599 Oligonucleotide synthesis with alternative solvents 5 2004
8,703,728 Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini 0 2004
8,778,900 Modulation of eIF4E-BP1 expression 0 2005
7,468,431 Modulation of eIF4E-BP2 expression 7 2005
8,569,474 Double stranded constructs comprising one or more short strands hybridized to a longer strand 0 2005
7,884,086 Conjugates for use in hepatocyte free uptake assays 1 2005
8,377,897 Compositions and methods for non-parenteral delivery of oligonucleotides 1 2005
7,745,609 Antisense modulation of CD40 expression 4 2006
7,807,652 Modulation of eIF4E-BP2 expression 1 2006
8,129,515 Oligomeric compounds and compositions for the use in modulation of microRNAs 1 2007
7,759,480 Chloral-free DCA in oligonucleotide synthesis 0 2007
7,897,582 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 0 2007
8,198,253 Compositions and their uses directed to HBXIP 0 2007
8,101,585 Compositions and methods for the modulation of JNK proteins 0 2007
8,101,743 Modulation of transthyretin expression 1 2008
8,067,386 Modulation of eIF4E-BP2 expression 0 2008
7,964,579 Compositions and methods for topical delivery of oligonucleotides 0 2009
8,691,785 Compositions and methods for non-parenteral delivery of oligonucleotides 0 2013
8,697,860 Diagnosis and treatment of disease 0 2013
 
BOSTON PROBES, INC. (23)
6,485,901 Methods, kits and compositions pertaining to linear beacons 36 1998
6,355,421 Methods, kits and compositions pertaining to PNA molecular beacons 56 1998
6,326,479 Synthetic polymers and methods, kits or compositions for modulating the solubility of same 11 1999
6,361,942 Method, kits and compositions pertaining to detection complexes 14 1999
6,441,152 Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices 4 1999
7,981,599 Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair 0 2000
6,607,889 Methods, kits and compositions pertaining to detection complexes 6 2001
6,528,267 Methods, kits and compositions pertaining to PNA molecular beacons 10 2001
6,649,349 In-situ methods for analyzing target sequences using linear beacons 3 2001
6,770,442 Methods for modulating the solubility of synthetic polymers 0 2001
6,905,824 Methods for determining organisms not requiring the separation of fixative or excess probe 0 2001
7,256,275 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 5 2002
6,949,343 Methods, kits and compositions pertaining to PNA Molecular Beacons 1 2003
8,017,758 PNA oligomers, oligomer sets, methods and kits pertaining to the detection of Bacillus anthracis 2 2003
7,816,501 Compositions comprising a linked acceptor moiety 0 2003
7,674,585 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 2 2006
7,638,279 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 1 2006
7,884,053 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7,851,155 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7,745,126 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 1 2006
7,605,253 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7,566,420 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7,892,741 Methods, kits and compositions pertaining to linear beacons 0 2008
 
INGENEUS INC. (17)
6,060,242 PNA diagnostic methods 22 1997
6,251,591 Quantitative method for detecting nucleotide concentration 47 1998
6,046,004 Solution hybridization of nucleic acids with antisense probes having modified backbones 31 1998
6,645,733 Fluorescent intensity method for assaying binding between proteins or peptides 10 1999
6,403,313 Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators 4 1999
6,420,115 Cation mediated triplex hybridization assay 8 2000
6,911,536 Triplex and quadruplex catalytic hybridization 1 2000
6,927,027 Nucleic acid multiplex formation 4 2001
6,656,692 Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes 3 2001
7,220,541 Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions 1 2001
6,858,390 Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes 2 2001
6,613,524 Amperometric affinity assay and electrically stimulated complexes of nucleic acids 4 2001
6,924,108 Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues 2 2002
6,878,815 Heteropolymeric triplexes containing watson-crick triplets 2 2002
6,982,147 Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions 1 2002
7,052,844 Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism 1 2002
7,309,569 Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes 0 2002
 
GEN-PROBE INCORPORATED (13)
6,821,770 Polynucleotide matrix-based method of identifying microorganisms 17 2000
6,376,186 Polynucleotide probes for detection and quantitation of staphylococcus 6 2000
6,326,486 Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae 2 2000
6,235,484 Polynucleotide probes for detection and quantitation of actinomycetes 4 2000
7,081,527 Compositions, methods and kits for determining the presence of Cryptosporidium parvum organisms in a test sample 5 2001
7,790,877 Antisense oligonucleotides with increased RNase sensitivity 0 2002
8,153,772 Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 0 2003
8,679,789 Oligonucleotides comprising a molecular switch 0 2004
7,449,328 Probe matrix-based device for identifying microorganisms 0 2004
7,585,631 Method for obtaining purified RNA from viable oocysts 2 2006
8,703,421 0 2009
8,008,017 Compositions and methods for detecting the presence of cryptosporidium organisms in a test sample 1 2009
8,105,779 in a test sample 0 2011
 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (11)
7,070,928 Evolving new molecular function 18 2002
7,183,054 Assay for identifying biological targets of polynucleotide-binding compounds 0 2003
7,491,494 Evolving new molecular function 17 2003
7,557,068 Evolving new molecular function 8 2003
7,122,549 Saframycins, analogues and uses thereof 0 2004
7,771,935 Evolving new molecular function 8 2004
7,223,545 Evolving new molecular function 14 2004
7,998,904 Evolving new molecular function 5 2005
7,442,160 Evolving new molecular function 8 2005
8,017,323 Free reactant use in nucleic acid-templated synthesis 2 2006
8,206,914 Evolving new molecular function 0 2010
 
LIFE TECHNOLOGIES CORPORATION (10)
6,977,305 Modified carbocyanine dyes and their conjugates 57 2001
6,974,873 Modified carbocyanine dyes and their conjugates 38 2001
7,566,790 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates 8 2005
7,790,893 Modified carbocyanine dyes and their conjugates 5 2005
7,820,824 Modified carbocyanine dyes and their conjugates 4 2007
7,671,214 Modified carbocyanine dyes and their conjugates 6 2007
8,614,302 Modified carbocyanine dyes and their conjugates 0 2008
7,927,830 Modified carbocyanine dyes and their conjugates 3 2008
8,252,932 Modified carbocyanine dyes and their conjugates 2 2010
8,569,506 Modified carbocyanine dyes and their conjugates 0 2012
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (10)
6,680,172 Treatments and markers for cancers of the central nervous system 0 2000
7,850,961 Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist 9 2006
8,652,467 Dek protein compositions and methods of using the same 0 2006
7,723,112 Compositions and methods for treating and diagnosing cancer 3 2006
7,713,710 Isolation and use of solid tumor stem cells 7 2007
8,044,259 Determining the capability of a test compound to affect solid tumor stem cells 0 2007
8,148,147 Compositions and methods for treating and diagnosing pancreatic cancer 0 2008
7,939,263 Compositions and methods for treating and diagnosing cancer 0 2009
8,420,885 Determining the capability of a test compound to affect solid tumor stem cells 0 2011
8,501,472 Compositions and methods for treating and diagnosing pancreatic cancer 0 2012
 
QIAGEN GMBH (8)
6,977,148 Multiple displacement amplification 70 2001
6,617,137 Method of amplifying whole genomes without subjecting the genome to denaturing conditions 51 2001
7,553,619 Detection method using dissociated rolling circle amplification 2 2002
7,074,600 Amplification of denatured and stabilized nucleic acids 5 2002
6,977,153 Rolling circle amplification of RNA 30 2002
7,297,485 Method for nucleic acid amplification that results in low amplification bias 12 2003
7,955,795 Method of whole genome amplification with reduced artifact production 0 2003
8,309,303 Reverse transcription and amplification of RNA with simultaneous degradation of DNA 0 2006
 
PHIGENIX, INC. (7)
8,080,534 Targeting PAX2 for the treatment of breast cancer 1 2010
8,735,365 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
8,431,546 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
8,394,780 Targeting PAX2 for the treatment of breast cancer 0 2011
8,633,149 Targeting PAX2 for the treatment of breast cancer 0 2011
8,461,101 Targeting PAX2 for the treatment of breast cancer 0 2011
8,653,021 Targeting PAX2 for the treatment of breast cancer 0 2011
 
BRISTOL-MYERS SQUIBB COMPANY (5)
8,227,420 Method for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID 2 2010
8,148,332 Method for treating a rheumatic disease using a soluble TLA4 molecule 2 2011
8,497,247 Methods for treating type I diabetes mellitus by administering a soluble CTLA4 molecule 2 2012
8,722,632 Methods for treating Sjogrens syndrome by administering a soluble CTLA4 molecule 0 2013
8,703,718 Methods for treating juvenile rheumatoid arthritis by administering a soluble CTLA4 molecule 0 2013
 
DUKE UNIVERSITY (5)
6,770,449 Methods of assaying receptor activity and constructs useful in such methods 5 2001
7,279,324 Nucleic acid encoding G-protein coupled receptor with modified DRY motif 0 2002
7,138,240 Methods of assaying receptor activity 5 2002
7,541,151 Single-cell biosensor for the measurement of GPCR ligands in a test sample 0 2002
7,572,888 Methods of assaying receptor activity and constructs useful in such methods 0 2004
 
NABSYS, INC. (5)
8,278,047 Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment 0 2008
8,262,879 Devices and methods for determining the length of biopolymers and distances between probes bound thereto 0 2009
8,455,260 Tagged-fragment map assembly 0 2010
8,246,799 Devices and methods for analyzing biomolecules and probes bound thereto 1 2010
8,715,933 Assay methods using nicking endonucleases 0 2010
 
NIELSEN, PETER (5)
6,451,968 Peptide nucleic acids 7 1994
7,223,833 Peptide nucleic acid conjugates 3 1994
6,617,422 Peptide nucleic acid monomers and oligomers 2 1997
6,300,318 Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor 1 1997
6,632,919 Peptide nucleic acid monomers and oligomers 3 1998
 
NIELSEN, PETER E. (5)
7,569,659 Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents 0 1997
6,190,866 Methods of bacterial gene function determination using peptide nucleic acids 2 1998
6,350,853 Conjugated peptide nucleic acids having enhanced cellular uptake 7 1999
6,770,738 Higher order structure and binding of peptide nucleic acids 1 1999
6,734,161 Peptide nucleic acids having antibacterial activity 0 2000
 
NORTHWESTERN UNIVERSITY (5)
8,252,756 Nucleic acid functionalized nanoparticles for therapeutic applications 1 2006
8,507,200 Particles for detecting intracellular targets 0 2008
7,807,372 Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay 0 2008
8,481,760 Inhibition and treatment of prostate cancer metastasis 0 2009
8,742,141 Inhibition and treatment of prostate cancer metastasis 0 2013
 
YALE UNIVERSITY (5)
7,794,931 Riboswitches, methods for their use, and compositions for use with riboswitches 0 2003
7,618,776 Rolling circle replication reporter systems 5 2004
8,313,901 Methods and compositions related to the modulation of riboswitches 0 2006
8,309,356 Pseudocomplementary oligonucleotides for targeted gene therapy 0 2010
8,440,810 Riboswitches, methods for their use, and compositions for use with riboswitches 0 2011
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (5)
7,534,605 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 3 2005
8,067,573 Nucleic acid agents for downregulating H19 and methods of using same 0 2006
8,067,574 Nucleic acid agents for downregulating H19, and methods of using same 0 2008
7,928,083 H19 silencing nucleic acid agents for treating rheumatoid arthritis 0 2008
8,193,311 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 0 2011
 
GAMIDA CELL LTD. (4)
7,344,881 Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby 5 2003
7,955,852 Expansion of renewable stem cell populations 5 2004
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7,655,225 Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby 0 2008
 
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (4)
7,429,489 Methods of controlling proliferation and differentiation of stem and progenitor cells 0 2004
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MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (4)
6,472,209 Using polyamide nucleic acid oligomers to engender a biological response 2 1997
6,743,627 Using polyamide nucleic acid oligomers to engender a biological response 1 1998
6,989,270 Using polyamide nucleic acid oligomers to engender a biological response 0 1998
6,723,560 Using polyamide nucleic acid oligomers to engender a biological response 0 1998
 
SIGMA-ALDRICH CO. (4)
6,737,236 Bioconjugation of macromolecules 20 1999
7,427,678 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method 9 2001
7,615,629 Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support 0 2002
7,098,326 Methods for the integrated synthesis and purification of oligonucleotides 0 2003
 
ALNYLAM PHARMACEUTICALS, INC. (3)
7,320,965 Compositions and methods for inhibiting expression of Huntingtin gene 26 2006
7,749,978 Compositions and methods for inhibiting expression of Huntingtin gene 5 2007
8,314,075 Compositions and methods for inhibiting expression of huntingtin gene 0 2011
 
DAKO DENMARK A/S (3)
6,110,676 Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays 94 1997
6,962,778 Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays 4 2000
7,306,916 Methods for detecting chromosome aberrations 0 2005
 
FREESLATE, INC. (3)
6,692,914 Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto 24 2000
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ONCOIMMUNIN, INC. (3)
6,936,687 Compositions for the detection of enzyme activity in biological samples and methods of use thereof 5 1999
7,541,143 Homo-doubly labeled compositions for the detection of enzyme activity in biological samples 1 2004
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ONCOMED PHARMACEUTICALS, INC. (3)
8,324,361 Nucleic acid molecules encoding soluble frizzled (FZD) receptors 0 2010
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8,592,386 Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis 0 2009
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UNIVERSITE LAVAL (3)
7,709,207 Method for identifying compounds for treatment of pain 0 2004
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ACTIVE MOTIF (2)
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ADVANDX, INC. (2)
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APPLIED BIOSYSTEMS, LLC (2)
6,331,618 Compositions of solvents and high concentrations of nucleic acid analogs 0 1999
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CELLSCRIPT, INC. (2)
7,413,857 Methods for using riboprimers for strand displacement replication of target sequences 2 2003
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COMPUGEN LTD. (2)
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CYTYC CORPORATION (2)
6,936,443 Detection and typing of human papillomavirus using PNA probes 6 2002
7,803,530 Detection and typing of human papillomavirus using PNA probes 0 2002
 
DRUG ROYALTY TRUST 9 (2)
6,660,845 Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof 30 1999
6,972,328 Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof 0 2003
 
Genentech, Inc. (2)
6,872,704 Acidic mammalian proteins and polynucleotides encoding the same 0 2002
7,803,915 Antibody compositions for the diagnosis and treatment of tumor 0 2004
 
MCGILL UNIVERSITY (2)
8,278,103 Oligonucleotides comprising alternating segments and uses thereof 0 2003
7,700,272 Polynucleotides encoding acetylcholine-gated chloride channel subunits of Caenorhabditis elegans 3 2005
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (2)
7,964,577 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2006
8,318,692 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
 
MORPHOTEK, INC. (2)
7,754,450 Methods of generating high-production of antibodies from hybridomas created by in vitro immunization 2 2003
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ONCOLMMUNIN, INC. (2)
6,893,868 Homo-doubly labeled compositions for the detection of enzyme activity in biological samples 4 2000
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PNA DIAGNOSTICS A/S (2)
5,861,250 Protecting nucleic acids and methods of analysis 9 1996
6,346,378 Nucleic acid analogs with a chelating functionality 0 1998
 
UNIVERSITY OF UTAH (2)
7,994,130 Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability 0 2007
8,309,519 Compositions and methods for inhibiting vascular permeability 0 2011
 
UNIVERSITY OF WASHINGTON (2)
7,138,259 PDEs and uses thereof 1 2001
7,598,067 PDEs and uses thereof 0 2006
 
VANDERBILT UNIVERSITY (2)
6,312,956 Nuclear targeted peptide nucleic acid oligomer 17 1999
6,623,966 Nuclear targeted peptide nucleic acid oligomer 4 2001
 
YEDA RESEARCH AND DEVELOPMENT CO. LTD. (2)
7,176,181 Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth 1 2002
7,416,725 Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth 0 2006
 
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8,043,834 Universal reagents for rolling circle amplification and methods of use 0 2003
 
ALT SOLUTIONS INC. (1)
8,778,906 Modulation of line-1 reverse transcriptase 0 2008
 
AMERSHAM PLC (1)
6,656,700 Isoforms of human pregnancy-associated protein-E 1 2001
 
ARROWHEAD RESEARCH CORPORATION (1)
8,809,293 Compositions and methods for inhibiting gene expression of hepatitis B virus 0 2012
 
Atom Sciences, Inc. (1)
5,821,060 DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA 29 1996
 
AVENTIS PHARMA DEUTSCHLAND GMBH (1)
6,316,595 PNA synthesis using a base-labile amino protecting group 0 2000
 
AVI BIOPHARMA, INC. (1)
6,060,246 Reagent and method for isolation and detection of selected nucleic acid sequences 60 1997
 
Baltic Technology Development, Ltd. (1)
7,786,292 Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease 0 2007
 
Bayer Aktiengesellschaft (1)
5,849,893 Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics 3 1996
 
BIOCEPT, INC. (1)
6,433,134 Peptide nucleic acid precursors and methods of preparing same 11 2000
 
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (1)
5,844,110 Synthetic triple helix-forming compound precursors 7 1995
 
BOSTON PROBEE, INC. (1)
7,422,852 Detection of nucleic acid using linear beacons 1 2003
 
Capitol Genomix, Inc. (1)
7,052,840 Reversible association of nucleic acid with a carboxylated substrate 0 2002
 
CHANG GUNG UNIVERSITY (1)
7,803,543 Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe 0 2007
 
CHILDRENS HOSPITAL LOS ANGELES (1)
7,951,785 NFIA in glial fate determination, glioma therapy and astrocytoma treatment 0 2008
 
CODEXIS, INC. (1)
8,614,081 Nitrilase biocatalysts 0 2010
 
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS (1)
6,673,544 Method for the light-controlled synthesis of biochips 1 2001
 
EMD MILLIPORE CORPORATION (1)
7,091,348 Fluorescent dyes, energy transfer couples and methods 7 2003
 
GE HEALTHCARE LIMITED (1)
6,686,188 Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle 0 2001
 
GILEAD SCIENCES, INC. (1)
5,763,424 Composition and method for storing nucleotide analogs 0 1996
 
Hoechst Aktiengesellschaft (1)
6,121,418 PNA synthesis using a base-labile amino protecting group 0 1997
 
Immune Modulation Maximum (1)
5,849,196 Composition containing peptides and nucleic acids and methods of making same 8 1996
 
LONZA COLOGNE GMBH (1)
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LORNE PARK RESEARCH USA, LLC (1)
5,846,729 Assaying nucleotides in solution using a fluorescent intensity quenching effect 40 1997
 
LUMINEX CORPORATION (1)
8,324,359 Oxocarbonamide peptide nucleic acids and methods of using same 0 2007
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
8,445,228 Enhancement of in vitro translation by nanoparticle conjugates 0 2009
 
Medical Research Fund of Tel Aviv Souraskv Medical Center (1)
8,076,087 Galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases 0 2006
 
MERCK SHARP & DOHME CORP. (1)
6,171,794 Methods for determining cross-hybridization 7 1999
 
MS TECHNOLOGIES, LLC (1)
7,749,504 Anti-TAT188 antibodies 0 2007
 
MYCOLOGICS, INC. (1)
6,716,625 Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use 0 2000
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
7,476,733 Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease 1 2005
 
Neilsen, Peter E. (1)
6,686,442 Conjugated peptide nucleic acids having enhanced cellular uptake 0 2001
 
OHR PHARMACEUTICAL, INC. (1)
8,084,239 Preparation of a therapeutic composition 0 2009
 
OncoMed Pharmaceuticals (1)
8,551,789 Frizzled-binding agents and their use in screening for WNT inhibitors 1 2011
 
PROLIGO L.L.C., A LIMITED LIABILITY COMPANY OF DELAWARE (1)
5,874,532 Method for solution phase synthesis of oligonucleotides and peptides 17 1997
 
PROLIGO LLC (1)
6,001,966 Method for solution phase synthesis of oligonucleotides and peptides 11 1998
 
PROMEGA CORPORATION (1)
8,309,059 Reactive cyanine compounds 0 2010
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (1)
7,741,304 Casein kinase 2 antisense therapy 0 2007
 
ROBERT BOSCH GMBH (1)
8,463,526 Method for detecting a periodically pulsing operating parameter 0 2008
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
7,833,729 Method for detecting endometriosis in a patient sample 0 2009
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
6,960,457 Reversible immobilization of arginine-tagged moieties on a silicate surface 5 2000
 
The Penn State Research Foundation (1)
5,968,748 Antisense oligonucleotide modulation of human HER-2 expression 34 1998
 
The Trustees of Columbia University in the City of New York (1)
7,329,649 Combinatorial methods for inducing cancer cell death 0 2004
 
THE UAB RESEARCH FOUNDATION (1)
8,557,767 Synthetic apolipoprotein E mimicking polypeptides and methods of use 0 2008
 
The United States of America as represented by the Secretary of the Navy (1)
8,691,729 Reaction discovery system 0 2008
 
THIEN, DOUGLAS Y. (1)
6,303,799 Polynucleotide crosslinking agents 2 1998
 
UNIVERSITY OF MASSACHUSETTS (1)
7,794,951 SREBP2gc transcription factors and uses thereof 0 2005
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
8,022,046 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes 0 2009
 
Other [Check patent profile for assignment information] (8)
6,395,474 Peptide nucleic acids 22 1993
6,357,163 Use of nucleic acid analogues in diagnostics and analytical procedures 8 1994
6,713,602 Synthetic procedures for peptide nucleic acids 4 1995
6,710,163 Peptide nucleic acid synthons 3 1995
6,414,112 Peptide nucleic acids having 2,6-diaminopurine nucleobases 11 1996
6,710,164 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility 1 1999
7,378,485 Peptide nucleic acids with polyamide-containing backbones 0 2002
8,568,766 Peptides and peptide mimetics to treat pathologies associated with eye disease 0 2008