Peptide nucleic acids

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5539082
SERIAL NO

08054363

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

  • Assignment data not available. Check PTO

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berg, Rolf H Strandvaenget 6, DK 2960 Rungsted Kyst, DK 14 615
Buchardt, Ole Sondergardsvej 73, DK 3500 Vaerlose, DK 32 723
Egholm, Michael Johnstrup Alle 3, DK 1923 Frederiksberg, DK 64 2020
Nielsen, Peter E Hjortevanget 509, DK 2980 Kokkedal, DK 29 661

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MONSANTO COMPANY (1)
* 5134066 Improved probes using nucleosides containing 3-dezauracil analogs 210 1989
 
NEU-GENE DEVELOPMENT GROUP, A CORP. OF OR (1)
* 5142047 Uncharged polynucleotide-binding polymers 139 1987
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Medical Research Fund of Tel Aviv (1)
* 2005/0221,326 Oligonucleotides antibodies and kits including same for treating prostate cancer and determining predisposition thereto 0 2004
 
Other [Check patent profile for assignment information] (21)
* 6395474 Peptide nucleic acids 33 1993
* 6357163 Use of nucleic acid analogues in diagnostics and analytical procedures 13 1994
* 6713602 Synthetic procedures for peptide nucleic acids 5 1995
* 6710163 Peptide nucleic acid synthons 3 1995
* 6414112 Peptide nucleic acids having 2,6-diaminopurine nucleobases 12 1996
* 6710164 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility 1 1999
7378485 Peptide nucleic acids with polyamide-containing backbones 1 2002
* 2003/0211,509 TNF-delta ligand and uses thereof 1 2002
* 2004/0092,470 Dry powder oligonucleotide formualtion, preparation and its uses 50 2003
* 2006/0160,731 Peptide nucleic acids 1 2003
* 2007/0021,361 Methods and materials for modulating trpm2 0 2003
* 2007/0042,978 Nf-hev compositions and methods of use 17 2003
* 2005/0009,041 Peptide nucleic acids and synthetic procedures therefor 1 2004
* 2006/0046,255 Use of nucleic acid analogues in diagnostics and analytical procedures 0 2005
* 2006/0281,102 Methods for detecting genetic haplotypes by interaction with probes 0 2006
* 2006/0205,004 Reversible association of nucleic acid with a carboxylated substrate 0 2006
8568766 Peptides and peptide mimetics to treat pathologies associated with eye disease 0 2008
* 2011/0091,454 METHODS AND SYSTEMS FOR ANNOTATING BIOMOLECULAR SEQUENCES 5 2010
* 8927271 Compositions and methods for detecting target analytes 0 2011
9593374 Composition and method for determination of CK19 expression 0 2013
9598693 Oligomeric compounds and compositions for the use in modulation of micrornas 0 2015
 
Medical Research Fund of Tel Aviv Souraskv Medical Center (1)
8076087 Galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases 0 2006
 
ARMUNE BIOSCIENCES, INC. (1)
* 2011/0237,461 USING PHAGE EPITOPES TO PROFILE THE IMMUNE RESPONSE 2 2011
 
INGENEUS INC. (23)
* 6060242 PNA diagnostic methods 22 1997
6251591 Quantitative method for detecting nucleotide concentration 47 1998
* 6046004 Solution hybridization of nucleic acids with antisense probes having modified backbones 34 1998
6645733 Fluorescent intensity method for assaying binding between proteins or peptides 10 1999
6403313 Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators 4 1999
6420115 Cation mediated triplex hybridization assay 8 2000
6911536 Triplex and quadruplex catalytic hybridization 1 2000
6927027 Nucleic acid multiplex formation 5 2001
6656692 Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes 3 2001
7220541 Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions 1 2001
* 2002/0137,056 Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions 2 2001
6858390 Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes 2 2001
6613524 Amperometric affinity assay and electrically stimulated complexes of nucleic acids 5 2001
6924108 Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues 2 2002
6878815 Heteropolymeric triplexes containing watson-crick triplets 2 2002
6982147 Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions 1 2002
* 2002/0123,066 Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions 0 2002
* 2003/0170,659 Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding 2 2002
7052844 Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism 2 2002
* 2003/0049,673 Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism 3 2002
7309569 Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes 0 2002
* 2003/0181,412 Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses 7 2003
* 2003/0180,790 Electrically stimulated complexes of nucleic acids 2 2003
 
CELLSCRIPT, INC. (3)
7413857 Methods for using riboprimers for strand displacement replication of target sequences 9 2003
* 2004/0180,361 Methods for using riboprimers for strand displacement replication of target sequences 0 2003
7659072 Methods for using riboprimers for strand displacement replication of target sequences 0 2008
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
* 2004/0005,611 PNA probes, probe sets, methods and kits pertaining to the determination of Listeria 0 2003
 
The United States of America as represented by the Department of Health and Human Services (2)
7476733 Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease 3 2005
9326992 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA 0 2012
 
HOECHST AKTIENGESELLSCHAFT (1)
* 6121418 PNA synthesis using a base-labile amino protecting group 1 1997
 
UNIVERSITY OF UTAH (2)
7994130 Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability 0 2007
8309519 Compositions and methods for inhibiting vascular permeability 0 2011
 
ABBOTT MOLECULAR INC. (1)
9365902 Detection of bisulfite converted nucleotide sequences 0 2014
 
BIOCEPT, INC. (1)
6433134 Peptide nucleic acid precursors and methods of preparing same 14 2000
 
MCGILL UNIVERSITY (4)
8278103 Oligonucleotides comprising alternating segments and uses thereof 0 2003
* 2005/0142,535 Ogligonucleotides comprising alternating segments and uses thereof 30 2005
7700272 Polynucleotides encoding acetylcholine-gated chloride channel subunits of Caenorhabditis elegans 3 2005
* 2008/0260,750 Polynucleotides Encoding Acetylcholine-Gated Chloride Channel Subunits of Caenorhabditis Elegans 0 2005
 
SIGMA-ALDRICH CO. (6)
6737236 Bioconjugation of macromolecules 35 1999
7427678 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method 19 2001
7615629 Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support 2 2002
* 2006/0149,046 Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support 24 2002
7098326 Methods for the integrated synthesis and purification of oligonucleotides 0 2003
* 2003/0195,351 Methods for the integrated synthesis and purification of oligonucleotides 1 2003
 
SAREPTA THERAPEUTICS, INC. (8)
8592386 Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis 16 2009
8697858 Antisense antiviral compound and method for treating influenza viral infection 17 2010
8779128 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups 19 2011
9278987 Functionally-modified oligonucleotides and subunits thereof 0 2012
9066967 Oligonucleotide analogues targeting human LMNA 0 2012
9249243 Antibacterial antisense oligonucleotide and method 0 2013
9394323 Antisense antiviral compound and method for treating influenza viral infection 0 2014
9469664 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups 0 2014
 
MERCK SHARP & DOHME CORP. (1)
6171794 Methods for determining cross-hybridization 7 1999
 
OHR PHARMACEUTICAL, INC. (1)
8084239 Preparation of a therapeutic composition 0 2009
 
GOLDMAN SACHS BANK USA (1)
* 2002/0146,717 Compositions, methods and kits for determining the presence of cryptosporidium parvum organisms in a test sample 0 2001
 
MS TECHNOLOGIES, LLC (1)
7749504 Anti-TAT188 antibodies 0 2007
 
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE (1)
9040626 Nanofibers and morphology shifting micelles 0 2012
 
The University of British Columbia (2)
9139554 Amino lipids and methods for the delivery of nucleic acids 1 2009
9205102 Method for treatment of castration-resistant prostate cancer 0 2014
 
NABSYS 2.0 LLC (15)
* 2007/0190,542 HYBRIDIZATION ASSISTED NANOPORE SEQUENCING 74 2006
8278047 Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment 2 2008
8882980 Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels 0 2009
8262879 Devices and methods for determining the length of biopolymers and distances between probes bound thereto 10 2009
* 2010/0096,268 USE OF LONGITUDINALLY DISPLACED NANOSCALE ELECTRODES FOR VOLTAGE SENSING OF BIOMOLECULES AND OTHER ANALYTES IN FLUIDIC CHANNELS 14 2009
8455260 Tagged-fragment map assembly 4 2010
* 2010/0261,285 TAGGED-FRAGMENT MAP ASSEMBLY 2 2010
* 2010/0243,449 DEVICES AND METHODS FOR ANALYZING BIOMOLECULES AND PROBES BOUND THERETO 31 2010
8246799 Devices and methods for analyzing biomolecules and probes bound thereto 7 2010
* 2010/0310,421 DEVICES AND METHODS FOR ANALYZING BIOMOLECULES AND PROBES BOUND THERETO 15 2010
8715933 Assay methods using nicking endonucleases 6 2010
8859201 Methods for sequencing a biomolecule by detecting relative positions of hybridized probes 1 2011
8926813 Devices and methods for determining the length of biopolymers and distances between probes bound thereto 0 2012
9051609 Biopolymer Sequencing By Hybridization of probes to form ternary complexes and variable range alignment 0 2012
9434981 Assay methods using nicking endonucleases 0 2014
 
UNIVERSITY OF WASHINGTON (3)
7138259 PDEs and uses thereof 1 2001
7598067 PDEs and uses thereof 0 2006
* 2007/0116,705 NOVEL PDEs AND USES THEREOF 0 2006
 
YEDA RESEARCH AND DEVELOPMENT CO. LTD. (2)
7176181 Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth 1 2002
7416725 Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth 0 2006
 
Baltic Technology Development, Ltd. (1)
7786292 Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease 0 2007
 
ANTISENSE PHARMA GMBH (2)
* 2007/0155,685 Pharmaceutical composition 12 2005
* 2011/0136,893 OLIGONUCLEOTIDE-, PROTEIN AND/OR PEPTIDE-POLYMER CONJUGATES 0 2007
 
BBM HOLDINGS, INC. (1)
* 2009/0305,944 Methods for Providing Palliative Care with AVR 118 1 2005
 
Atom Sciences, Inc. (1)
* 5821060 DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA 32 1996
 
COMPUGEN LTD. (6)
7842459 Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 2 2005
8415455 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 2 2008
9428574 Polypeptides and uses thereof for treatment of autoimmune disorders and infection 0 2012
9107862 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 1 2013
9375466 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 0 2013
9555087 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 0 2014
 
LIFE TECHNOLOGIES CORPORATION (20)
6977305 Modified carbocyanine dyes and their conjugates 86 2001
6974873 Modified carbocyanine dyes and their conjugates 61 2001
7566790 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates 13 2005
* 2006/0004,188 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates 35 2005
7790893 Modified carbocyanine dyes and their conjugates 11 2005
7820824 Modified carbocyanine dyes and their conjugates 9 2007
7671214 Modified carbocyanine dyes and their conjugates 11 2007
* 2007/0232,805 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 28 2007
* 2007/0178,511 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 27 2007
* 2007/0178,512 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 22 2007
8614302 Modified carbocyanine dyes and their conjugates 2 2008
7927830 Modified carbocyanine dyes and their conjugates 8 2008
* 2009/0035,809 Modified Carbocyanine Dyes and Their Conjugates 17 2008
* 2009/0035,810 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 9 2008
* 2011/0014,617 Methods and Systems for Detecting Nucleic Acids 0 2010
8252932 Modified carbocyanine dyes and their conjugates 4 2010
* 2011/0171,678 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 5 2010
8569506 Modified carbocyanine dyes and their conjugates 6 2012
9018396 Modified carbocyanine dyes and their conjugates 1 2013
9423323 Modified carbocyanine dyes and their conjugates 0 2015
 
DUKE UNIVERSITY (9)
6770449 Methods of assaying receptor activity and constructs useful in such methods 6 2001
7279324 Nucleic acid encoding G-protein coupled receptor with modified DRY motif 0 2002
* 2003/0049,643 Constitutively desensitized G protein-coupled receptors 1 2002
* 2003/0182,669 Phosphoinositide 3-kinase mediated inhibition of GPCRs 3 2002
7138240 Methods of assaying receptor activity 5 2002
7541151 Single-cell biosensor for the measurement of GPCR ligands in a test sample 0 2002
7572888 Methods of assaying receptor activity and constructs useful in such methods 0 2004
* 2004/0209,308 Methods of assaying receptor activity and constructs useful in such methods 0 2004
* 2006/0026,702 Phosphoinositide 3-kinase mediated inhibition of GPCRs 5 2004
 
GAMIDA CELL LTD. (7)
7344881 Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby 9 2003
7955852 Expansion of renewable stem cell populations 8 2004
8846393 Methods of improving stem cell homing and engraftment 0 2006
8080417 Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells 6 2006
7655225 Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby 0 2008
9567569 Methods of culturing and expanding mesenchymal stem cells 0 2013
9175266 Enhancement of natural killer (NK) cell proliferation and activity 1 2013
 
MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (1)
* 2001/0039,263 Chimeric oligonucleotides and the use thereof 55 2001
 
UNIVERSITY OF CHICAGO, THE (1)
9499817 Antisense polynucleotides to induce exon skipping and methods of treating dystrophies 0 2013
 
Genentech, Inc. (2)
6872704 Acidic mammalian proteins and polynucleotides encoding the same 0 2002
7803915 Antibody compositions for the diagnosis and treatment of tumor 3 2004
 
PROLIGO LLC (1)
* 6001966 Method for solution phase synthesis of oligonucleotides and peptides 13 1998
 
The United States of America as represented by the Secretary of the Navy (1)
8691729 Reaction discovery system 0 2008
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
8318692 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
 
IONIS PHARMACEUTICALS, INC. (2)
8916531 Modulation of CD40 expression 0 2008
9399774 Modulation of transthyretin expression 0 2015
 
Immune Modulation Maximum (1)
* 5849196 Composition containing peptides and nucleic acids and methods of making same 8 1996
 
LORNE PARK RESEARCH USA, LLC (1)
* 5846729 Assaying nucleotides in solution using a fluorescent intensity quenching effect 53 1997
 
PROLIGO L.L.C., A LIMITED LIABILITY COMPANY OF DELAWARE (1)
* 5874532 Method for solution phase synthesis of oligonucleotides and peptides 23 1997
 
UAB RESEARCH FOUNDATION, THE (2)
9422363 Synthetic apolipoprotein E mimicking polypeptides and methods of use 0 2008
8557767 Synthetic apolipoprotein E mimicking polypeptides and methods of use 0 2008
 
ISIS PHARMACEUTICALS, INC. (83)
* 6077833 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 23 1996
6339066 Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate .beta.I, .beta.II, .gamma., .delta., .EPSILON., .zeta. and .eta. isoforms of human protein kinase C 4 1997
* 6015887 Chiral peptide nucleic acids and methods for preparing same 11 1997
* 5985558 Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos 41 1997
* 6893815 Nucleobase heterocyclic combinatorialization 0 1997
* 5877309 Antisense oligonucleotides against JNK 69 1997
7321828 System of components for preparing oligonucleotides 109 1998
* 6117847 Oligonucleotides for enhanced modulation of protein kinase C expression 3 1998
6528631 Oligonucleotide-folate conjugates 91 1998
6300319 Targeted oligonucleotide conjugates 38 1998
6887906 Compositions and methods for the delivery of oligonucleotides via the alimentary canal 42 1998
* 6277603 PNA-DNA-PNA chimeric macromolecules 5 1998
6221850 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 9 1998
6175004 Process for the synthesis of oligonucleotides incorporating 2-aminoadenosine 4 1998
6225293 Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations 0 1998
* 6069243 Process for oligonucleotide synthesis 15 1998
6492111 In situ binary synthesis of biologically effective molecules 0 1998
6300320 Modulation of c-jun using inhibitors of protein kinase C 0 1999
6399765 Methods for removing dimethoxytrityl groups from oligonucleotides 3 1999
6335434 Nucleosidic and non-nucleosidic folate conjugates 135 1999
* 6133246 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 109 1999
8153602 Composition and methods for the pulmonary delivery of nucleic acids 2 1999
6841539 Compositions and methods for topical delivery of oligonucleotides 18 1999
6319906 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 14 1999
6656730 Oligonucleotides conjugated to protein-binding drugs 84 1999
* 6613873 Peptide nucleic acids having 2,6-diaminopurine nucleobases 3 1999
6593466 Guanidinium functionalized nucleotides and precursors thereof 13 1999
6312900 Antisense oligonucleotide compositions and methods for the modulation of activating protein 1 19 1999
6753423 Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals 12 2000
6762169 Ligand-conjugated oligomeric compounds 60 2000
6534639 Guanidinium functionalized oligonucleotides and method/synthesis 23 2000
6809193 Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 17 2001
6525031 Targeted Oligonucleotide conjugates 26 2001
6861514 Nucleosidic and non-nucleosidic folate conjugates 50 2001
6537973 Oligonucleotide inhibition of protein kinase C 8 2001
6747014 Compositions and methods for non-parenteral delivery of oligonucleotides 54 2001
6921812 Methods of modulating pharmacokinetics of oligonucleotides 2 2002
7695902 Oligoribonucleotides and ribonucleases for cleaving RNA 73 2002
* 2003/0191,075 Method of using modified oligonucleotides for hepatic delivery 52 2002
6794502 Methods for removing dimethoxytrityl groups from oligonucleotides 0 2002
* 2003/0207,804 Modified peptide nucleic acids 16 2002
7038037 Method for sequential support-bound synthesis of conjugated oligomeric compounds 0 2002
* 2002/0192,700 In situ binary synthesis of biologically effective molecules 0 2002
6914148 Guanidinium functionalized intermediates 3 2002
* 2004/0063,618 Peptide nucleic acids having improved uptake and tissue distribution 4 2002
6660720 Targeted oligonucleotide conjugates 6 2002
7002006 Protection of nucleosides 2 2003
7169916 Chloral-free DCA in oligonucleotide synthesis 53 2003
* 2004/0023,917 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 0 2003
7235653 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 51 2003
* 2004/0235,164 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 1 2003
9096636 Chimeric oligomeric compounds and their use in gene modulation 0 2003
8604183 Compositions comprising alternating 2′-modified nucleosides for use in gene modulation 1 2003
7812149 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations 3 2003
* 2004/0142,899 Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals 0 2004
8394947 Positionally modified siRNA constructs 0 2004
7960355 Compositions and methods for the modulation of the expression of B7 protein 0 2004
7276599 Oligonucleotide synthesis with alternative solvents 53 2004
* 2005/0026,192 Oligonucleotide synthesis with alternative solvents 2 2004
8703728 Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini 0 2004
8778900 Modulation of eIF4E-BP1 expression 0 2005
7468431 Modulation of eIF4E-BP2 expression 55 2005
8569474 Double stranded constructs comprising one or more short strands hybridized to a longer strand 0 2005
7884086 Conjugates for use in hepatocyte free uptake assays 4 2005
8377897 Compositions and methods for non-parenteral delivery of oligonucleotides 1 2005
7745609 Antisense modulation of CD40 expression 50 2006
7807652 Modulation of eIF4E-BP2 expression 1 2006
* 2007/0149,472 ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS 0 2006
8129515 Oligomeric compounds and compositions for the use in modulation of microRNAs 11 2007
7759480 Chloral-free DCA in oligonucleotide synthesis 0 2007
* 2007/0123,703 CHLORAL-FREE DCA IN OLIGONUCLEOTIDE SYNTHESIS 0 2007
7897582 Oligonucleotide compositions and methods for the modulation of the expression of B7 protein 0 2007
* 2008/0027,019 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN 2 2007
8198253 Compositions and their uses directed to HBXIP 0 2007
8101585 Compositions and methods for the modulation of JNK proteins 2 2007
* 2008/0255,030 COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS 3 2007
8101743 Modulation of transthyretin expression 8 2008
8067386 Modulation of eIF4E-BP2 expression 0 2008
7964579 Compositions and methods for topical delivery of oligonucleotides 2 2009
9127272 Oligomeric compounds and compositions for the use in modulation of target nucleic acids 0 2012
8691785 Compositions and methods for non-parenteral delivery of oligonucleotides 32 2013
8697860 Diagnosis and treatment of disease 2 2013
9061044 Modulation of transthyretin expression 0 2014
 
THIEN, DOUGLAS Y. (1)
6303799 Polynucleotide crosslinking agents 5 1998
 
ALT SOLUTIONS INC. (3)
* 2009/0099,060 Modulation of line-1 reverse transcriptase 0 2005
8778906 Modulation of line-1 reverse transcriptase 0 2008
* 2009/0036,391 Modulation of line-1 reverse transcriptase 0 2008
 
PALADIN LABS INC. (1)
9090649 Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof 0 2009
 
Active Motif (4)
7115738 Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use 0 2001
6962906 Oligonucleotide analogues, methods of synthesis and methods of use 11 2002
* 2003/0059,789 Oligonucleotide analogues, methods of synthesis and methods of use 5 2002
* 2004/0014,644 Oligonucleotide analogues and methods of use for modulating gene expression 1 2003
 
DAKOCYTOMATION A/S (1)
* 2003/0129,626 Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid 7 2002
 
NORTHWESTERN UNIVERSITY (10)
8252756 Nucleic acid functionalized nanoparticles for therapeutic applications 2 2006
8507200 Particles for detecting intracellular targets 0 2008
9506056 Nucleic acid functionalized nanoparticles for therapeutic applications 0 2008
7807372 Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay 0 2008
* 2008/0311,669 SCREENING SEQUENCE SELECTIVITY OF OLIGONUCLEOTIDE-BINDING MOLECULES USING NANOPARTICLE BASED COLORIMETRIC ASSAY 2 2008
8481760 Inhibition and treatment of prostate cancer metastasis 0 2009
9139827 Polyvalent RNA-nanoparticle compositions 0 2009
9376690 Templated nanoconjugates 0 2010
8999947 Nucleic acid functionalized nanoparticles for therapeutic applications 0 2012
8742141 Inhibition and treatment of prostate cancer metastasis 0 2013
 
EMERALD THERAPEUTICS, INC. (1)
9289502 Preparation of oligo conjugates 0 2013
 
DRUG ROYALTY TRUST 9 (3)
6660845 Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof 63 1999
6972328 Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof 2 2003
* 2004/0116,689 Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof 42 2003
 
UNIVERSITE LAVAL (6)
7709207 Method for identifying compounds for treatment of pain 0 2004
* 2007/0092,510 Cns chloride modulation and uses thereof 3 2004
7718382 Method for identifying compounds for treatment of pain 4 2005
* 2008/0260,718 Phospholipase C Gamma Modulation and Uses Thereof for Management of Pain and Nociception 0 2005
8173376 Method for identifying compounds for treatment of pain 0 2010
* 2010/0330,586 METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF PAIN 0 2010
 
NEILSEN, PETER E. (1)
6686442 Conjugated peptide nucleic acids having enhanced cellular uptake 0 2001
 
ARROWHEAD RESEARCH CORPORATION (7)
* 2010/0197,773 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF PTP1B GENES 3 2010
* 2011/0020,300 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF GLUCOCORTICOID RECEPTOR (GCR) GENES 0 2010
* 2011/0112,176 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KIF10 GENES 0 2010
* 2011/0152,349 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF IL-18 GENES 0 2010
* 2011/0196,016 Compositions and Methods for Inhibiting Expression of IKK2 Genes 0 2011
8946176 Compositions and methods for inhibiting expression of RRM2 genes 0 2011
8809293 Compositions and methods for inhibiting gene expression of hepatitis B virus 5 2012
 
BECTON, DICKINSON AND COMPANY (1)
9404160 Methods for the detection of microorganisms 0 2010
 
REGENTS OF THE UNIVERSITY OF MICHIGAN, THE (26)
6680172 Treatments and markers for cancers of the central nervous system 0 2000
9492538 Isolation and use of solid tumor stem cells 0 2005
* 2006/0073,125 Isolation and use of solid tumor stem cells 32 2005
* 2007/0099,209 Compositions and methods for treating and diagnosing cancer 38 2006
7850961 Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist 20 2006
8652467 Dek protein compositions and methods of using the same 0 2006
* 2009/0004,197 Dek Protein Compositions and Methods of Using the Same 3 2006
7723112 Compositions and methods for treating and diagnosing cancer 11 2006
* 2008/0064,049 Compositions and methods for treating and diagnosing cancer 34 2006
* 2007/0212,737 Isolation and use of solid tumor stem cells 29 2006
* 2008/0019,961 Hedgehog signaling pathway antagonist cancer treatment 27 2007
7713710 Isolation and use of solid tumor stem cells 17 2007
8044259 Determining the capability of a test compound to affect solid tumor stem cells 1 2007
8148147 Compositions and methods for treating and diagnosing pancreatic cancer 0 2008
* 2008/0261,244 Compositions And Methods For Treating And Diagnosing Pancreatic Cancer 6 2008
* 2008/0292,546 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 10 2008
* 2008/0260,734 COMPOSITIONS AND METHODS FOR CHARACTERIZING, REGULATING, DIAGNOSING, AND TREATING CANCER 18 2008
7939263 Compositions and methods for treating and diagnosing cancer 2 2009
* 2010/0169,990 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 5 2009
* 2011/0033,481 PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS 16 2010
9267133 Phage microarray profiling of the humoral response to disease 0 2010
* 2011/0092,378 ISOLATION AND USE OF SOLID TUMOR STEM CELLS 16 2010
* 2011/0183,866 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 6 2011
8420885 Determining the capability of a test compound to affect solid tumor stem cells 0 2011
8501472 Compositions and methods for treating and diagnosing pancreatic cancer 0 2012
9089556 Method for treating cancer using an antibody that inhibits notch4 signaling 0 2013
 
PHIGENIX, INC. (8)
7964577 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2006
8080534 Targeting PAX2 for the treatment of breast cancer 1 2010
8735365 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
8431546 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy 0 2011
8394780 Targeting PAX2 for the treatment of breast cancer 0 2011
8633149 Targeting PAX2 for the treatment of breast cancer 0 2011
8461101 Targeting PAX2 for the treatment of breast cancer 0 2011
8653021 Targeting PAX2 for the treatment of breast cancer 0 2011
 
CYTYC CORPORATION (4)
6936443 Detection and typing of human papillomavirus using PNA probes 11 2002
* 2003/0143,529 Detection and typing of human papillomavirus using PNA probes 2 2002
7803530 Detection and typing of human papillomavirus using PNA probes 0 2002
* 2003/0108,866 Detection and typing of human papillomavirus using PNA probes 1 2002
 
PNA DIAGNOSTICS A/S (2)
* 5861250 Protecting nucleic acids and methods of analysis 9 1996
* 6346378 Nucleic acid analogs with a chelating functionality 0 1998
 
SYMYX TECHNOLOGIES, INC. (1)
* 2005/0158,879 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 0 2004
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (2)
7741304 Casein kinase 2 antisense therapy 0 2007
* 2008/0113,932 CASEIN KINASE 2 ANTISENSE THERAPY 0 2007
 
NIELSEN, PETER E. (5)
7569659 Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents 0 1997
6190866 Methods of bacterial gene function determination using peptide nucleic acids 2 1998
6350853 Conjugated peptide nucleic acids having enhanced cellular uptake 11 1999
* 6770738 Higher order structure and binding of peptide nucleic acids 1 1999
6734161 Peptide nucleic acids having antibacterial activity 0 2000
 
OncoMed Pharmaceuticals (2)
8551789 Frizzled-binding agents and their use in screening for WNT inhibitors 11 2011
9228013 Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell 0 2014
 
EPICENTRE TECHNOLOGIES CORPORATION (1)
* 2004/0197,802 Methods for using primers that encode one strand of a double-stranded promoter 44 2003
 
UNIVERSITY OF MASSACHUSETTS (2)
7794951 SREBP2gc transcription factors and uses thereof 0 2005
* 2007/0089,179 SREBP2gc transcription factors and uses thereof 0 2005
 
AGILIX CORPORATION (1)
8043834 Universal reagents for rolling circle amplification and methods of use 0 2003
 
UNIVERSITY OF MARYLAND, BALTIMORE (1)
* 2006/0281,121 Computing with biomolecules 4 2006
 
EMD MILLIPORE CORPORATION (1)
7091348 Fluorescent dyes, energy transfer couples and methods 24 2003
 
HALO-BIO RNAI THERAPEUTICS, INC. (1)
9200276 Polynucleotides for multivalent RNA interference, compositions and methods of use thereof 0 2010
 
GILEAD SCIENCES, INC. (1)
* 5763424 Composition and method for storing nucleotide analogs 0 1996
 
PROMEGA CORPORATION (1)
8309059 Reactive cyanine compounds 1 2010
 
LUMINEX CORPORATION (1)
8324359 Oxocarbonamide peptide nucleic acids and methods of using same 0 2007
 
ADVANDX, INC. (4)
* 8795972 Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy 0 2008
* 2009/0092,994 Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy 0 2008
8586314 (sensu stricto) 0 2010
* 2010/0285,987 PEPTIDE NUCLEIC ACID PROBES FOR DETECTION, IDENTIFICATION AND/OR QUANTITATION OF PSEUDOMONAS (SENSU STRICTO) 0 2010
 
AVI BIOPHARMA, INC. (1)
* 6060246 Reagent and method for isolation and detection of selected nucleic acid sequences 79 1997
 
QIAGEN GMBH (16)
6977148 Multiple displacement amplification 110 2001
* 2004/0161,742 Nucleic acid amplification 12 2001
6617137 Method of amplifying whole genomes without subjecting the genome to denaturing conditions 72 2001
7553619 Detection method using dissociated rolling circle amplification 3 2002
7074600 Amplification of denatured and stabilized nucleic acids 21 2002
* 2004/0121,338 Real-time detection of rolling circle amplification products 6 2002
* 2003/0165,948 Method and compositions for efficient and specific rolling circle amplification 8 2002
9487823 Nucleic acid amplification 0 2002
6977153 Rolling circle amplification of RNA 41 2002
* 2004/0126,770 Rolling circle amplification of RNA 7 2002
7297485 Method for nucleic acid amplification that results in low amplification bias 35 2003
* 2003/0228,613 Nucleic acid amplification 48 2003
7955795 Method of whole genome amplification with reduced artifact production 5 2003
* 2004/0248,105 Method of whole genome amplification with reduced artifact production 9 2003
8309303 Reverse transcription and amplification of RNA with simultaneous degradation of DNA 0 2006
* 2008/0128,298 NUCLEIC ACID AMPLIFICATION 1 2007
 
BOSTON PROBEE, INC. (1)
7422852 Detection of nucleic acid using linear beacons 2 2003
 
GEN-PROBE INCORPORATED (20)
6821770 Polynucleotide matrix-based method of identifying microorganisms 28 2000
6376186 Polynucleotide probes for detection and quantitation of staphylococcus 7 2000
6326486 Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae 4 2000
6235484 Polynucleotide probes for detection and quantitation of actinomycetes 6 2000
* 2003/0045,488 Antisense oligonucleotides comprising universal and/or degenerate bases 12 2001
7081527 Compositions, methods and kits for determining the presence of Cryptosporidium parvum organisms in a test sample 6 2001
7790877 Antisense oligonucleotides with increased RNase sensitivity 0 2002
* 2003/0165,888 Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 0 2002
8153772 Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 0 2003
* 2003/0170,711 Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 5 2003
8679789 Oligonucleotides comprising a molecular switch 0 2004
* 2005/0042,638 Oligonucleotides comprising a molecular switch 9 2004
7449328 Probe matrix-based device for identifying microorganisms 1 2004
7585631 Method for obtaining purified RNA from viable oocysts 2 2006
* 2007/0020,661 METHOD FOR OBTAINING PURIFIED RNA FROM VIABLE OOCYSTS 0 2006
8927703 English Title Not Available 0 2008
8703421 English Title Not Available 0 2009
8008017 Compositions and methods for detecting the presence of cryptosporidium organisms in a test sample 1 2009
8105779 in a test sample 0 2011
9243286 Methods of using oligonucleotides comprising a molecular switch 0 2014
 
Panagene, Inc. (1)
* 2010/0240,058 MicroRNA Antisense PNAs, Compositions Comprising the Same, and Methods for Using and Evaluating the Same 0 2008
 
NANOSTRING TECHNOLOGIES, INC. (1)
* 2011/0201,515 COMPOSITIONS AND METHODS FOR THE DETECTION OF SMALL RNAS 0 2011
 
HOFFMANN-LA ROCHE INC. (1)
* 2010/0124,547 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENES 2 2009
 
The Trustees of Columbia University in the City of New York (3)
* 2003/0082,140 Combinatorial methods for inducing cancer cell death 3 2001
7329649 Combinatorial methods for inducing cancer cell death 0 2004
* 2004/0191,223 Combinatorial methods for inducing cancer cell death 0 2004
 
VECTOR TOBACCO INC. (1)
9439452 Reduced risk tobacco products and methods of making same 0 2013
 
U.S. DEPARTMENT OF VETERANS AFFAIRS (1)
* 2005/0043,262 Novel specific inhibitor of the cyclin kinase inhibitor p21Waf1/Cip1 and methods of using the inhibitor 1 2004
 
GEISINGER CLINIC (1)
* 2006/0154,285 Zebrafish heterotrimer G-protein gamma 2 subunit (GNG2) 1 2005
 
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (1)
* 5844110 Synthetic triple helix-forming compound precursors 7 1995
 
LONZA COLOGNE GMBH (1)
6521456 Cellular transport system for the transfer of a nucleic acid through the nuclear envelope and methods thereof 3 2001
 
YALE UNIVERSITY (10)
* 2004/0115,643 Thermodynamic equilibrium extension of primers 3 2002
7794931 Riboswitches, methods for their use, and compositions for use with riboswitches 11 2003
* 2005/0053,951 Riboswitches, methods for their use, and compositions for use with riboswitches 10 2003
7618776 Rolling circle replication reporter systems 9 2004
8313901 Methods and compositions related to the modulation of riboswitches 0 2006
* 2009/0305,253 Methods and Compositions Related to the Modulation of Riboswitches 4 2006
* 2010/0286,082 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES 1 2008
8309356 Pseudocomplementary oligonucleotides for targeted gene therapy 0 2010
8440810 Riboswitches, methods for their use, and compositions for use with riboswitches 0 2011
* 2011/0150,854 RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES 0 2011
 
BRISTOL-MYERS SQUIBB COMPANY (7)
* 2002/0068,346 Modified inosine 5'-monophosphate dehydrogenase polypeptides and uses thereof 6 2001
8227420 Method for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID 3 2010
8148332 Method for treating a rheumatic disease using a soluble TLA4 molecule 3 2011
8497247 Methods for treating type I diabetes mellitus by administering a soluble CTLA4 molecule 3 2012
8722632 Methods for treating Sjogrens syndrome by administering a soluble CTLA4 molecule 0 2013
8703718 Methods for treating juvenile rheumatoid arthritis by administering a soluble CTLA4 molecule 0 2013
9296808 Methods for treating scleroderma by administering a soluble CTLA4 molecule 0 2014
 
OncoImmunin, Inc. (4)
6936687 Compositions for the detection of enzyme activity in biological samples and methods of use thereof 15 1999
7541143 Homo-doubly labeled compositions for the detection of enzyme activity in biological samples 1 2004
7879574 Compositions for the detection of enzyme activity in biological samples and methods of use thereof 0 2007
* 2008/0199,898 COMPOSITIONS FOR THE DETECTION OF ENZYME ACTIVITY IN BIOLOGICAL SAMPLES AND METHODS OF USE THEREOF 6 2007
 
AMERSHAM PLC (3)
6656700 Isoforms of human pregnancy-associated protein-E 4 2001
* 2004/0068,380 Human gtp-rho binding protein 2 0 2003
* 2004/0063,134 Novel isoforms of human pregnancy-associated protein-E 0 2003
 
ONCOMED PHARMACEUTICALS, INC. (12)
8324361 Nucleic acid molecules encoding soluble frizzled (FZD) receptors 0 2010
9157904 Wnt antagonists and methods of treatment and screening 3 2011
8507442 Methods of use for an antibody against human frizzled receptors 1, 2. 5, 7 or 8 11 2011
8765913 Human frizzled (FZD) receptor polypeptides and methods of use thereof for treating cancer and inhibiting growth of tumor cells 0 2012
9273139 Monoclonal antibodies against frizzled 2 2013
8975044 Polynucleotides encoding for frizzled-binding agents and uses thereof 0 2013
9499630 Frizzled-binding agents and uses thereof 0 2013
9266959 Methods of treating neuroendocrine tumors using frizzled-binding agents 2 2013
9359444 Methods and monitoring of treatment with a Wnt pathway inhibitor 0 2014
9168300 MET-binding agents and uses thereof 0 2014
9573998 Antibodies against human FZD5 and FZD8 0 2015
9579361 Wnt antagonist and methods of treatment and screening 0 2015
 
Arcxis Biotechnologies (1)
* 2008/0182,759 SELECTION OF APTAMERS BASED ON GEOMETRY 2 2007
 
University of Pittsburgh (1)
8022046 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes 0 2009
 
Bayer Aktiengesellschaft (1)
* 5849893 Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics 3 1996
 
EXIQON A/S (5)
* 2009/0137,504 MICRORNA TARGET SITE BLOCKING OLIGOS AND USES THEREOF 7 2007
* 2009/0053,718 NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs 11 2008
* 2009/0326,049 BLOCKING OLIGOS FOR INHIBITION OF MICRORNA AND SIRNA ACTIVITY AND USES THEREOF 14 2009
* 2010/0113,284 SMALL INTERFERING RNA (SIRNA) TARGET SITE BLOCKING OLIGOS AND USES THEREOF 4 2009
9464106 Oligonucleotides useful for detecting and analyzing nucleic acids of interest 0 2011
 
AVENTIS PHARMA DEUTSCHLAND GMBH (1)
6316595 PNA synthesis using a base-labile amino protecting group 0 2000
 
DEUTSCHES KREBSFORSCHUNGSZENTRUM (1)
* 6673544 Method for the light-controlled synthesis of biochips 1 2001
 
ROBERT BOSCH GMBH (1)
8463526 Method for detecting a periodically pulsing operating parameter 0 2008
 
INTEL CORPORATION (2)
* 2005/0064,435 Programmable molecular barcodes 15 2003
* 2006/0199,216 Programmable molecular barcodes 1 2006
 
GE HEALTHCARE LIMITED (3)
6686188 Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle 0 2001
* 2002/0048,800 Myosin-like gene expressed in human heart and muscle 0 2001
* 2004/0137,589 Human myosin-like polypeptide expressed predominantly in heart and muscle 0 2003
 
HOLOGIC, INC. (1)
* 2009/0253,142 COMPOSITIONS AND METHODS FOR ANALYSIS OF NUCLEIC ACID MOLECULES DURING AMPLIFICATION REACTIONS 19 2009
 
NIELSEN, PETER (5)
* 6451968 Peptide nucleic acids 9 1994
* 7223833 Peptide nucleic acid conjugates 13 1994
6617422 Peptide nucleic acid monomers and oligomers 4 1997
6300318 Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor 1 1997
* 6632919 Peptide nucleic acid monomers and oligomers 3 1998
 
Capitol Genomix, Inc. (2)
7052840 Reversible association of nucleic acid with a carboxylated substrate 0 2002
* 2003/0194,707 Reversible association of nucleic acid with a carboxylated substrate 0 2002
 
The Penn State Research Foundation (1)
* 5968748 Antisense oligonucleotide modulation of human HER-2 expression 37 1998
 
CODEXIS, INC. (1)
8614081 Nitrilase biocatalysts 0 2010
 
AXOLABS GMBH (1)
* 2011/0201,006 Oligonucleotide Detection Method 0 2009
 
FREESLATE, INC. (3)
6692914 Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto 35 2000
6833276 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 11 2001
7205161 Polymer brushes for immobilizing molecules to a surface or substrate having improved stability 2 2002
 
ELITECH HOLDING B.V. (2)
9085800 Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use 0 2012
8969003 Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use 0 2013
 
ACLARA BIOSCIENCES, INC. (1)
* 2003/0013,117 Multiplexed differential displacement for nucleic acid determinations 0 2002
 
MEDTRONIC, INC. (5)
7320965 Compositions and methods for inhibiting expression of Huntingtin gene 90 2006
* 2007/0099,860 Compositions and methods for inhibiting expression of huntingtin gene 9 2006
7749978 Compositions and methods for inhibiting expression of Huntingtin gene 52 2007
* 2008/0221,055 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HUNTINGTIN GENE 3 2007
8314075 Compositions and methods for inhibiting expression of huntingtin gene 0 2011
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (3)
8445228 Enhancement of in vitro translation by nanoparticle conjugates 1 2009
* 2011/0117,597 Enhancement of in vitro translation by nanoparticle conjugates 0 2009
9388445 Enhancement of in vitro translation by nanoparticle conjugates 0 2013
 
COLD SPRING HARBOR LABORATORY (1)
* 2005/0054,836 Chimeric molecules to modulate gene expression 8 2003
 
MICROSOFT TECHNOLOGY LICENSING, LLC (1)
* 2003/0222,908 Dynamic wizard interface system and method 4 2002
 
APPLIED BIOSYSTEMS, LLC (39)
6485901 Methods, kits and compositions pertaining to linear beacons 54 1998
* 6355421 Methods, kits and compositions pertaining to PNA molecular beacons 75 1998
* 6326479 Synthetic polymers and methods, kits or compositions for modulating the solubility of same 12 1999
6361942 Method, kits and compositions pertaining to detection complexes 15 1999
* 6331618 Compositions of solvents and high concentrations of nucleic acid analogs 4 1999
6441152 Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices 5 1999
7060432 Methods for the detection, identification, and/or enumeration of yeast, particularly in wine 1 2000
7981599 Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair 0 2000
6607889 Methods, kits and compositions pertaining to detection complexes 8 2001
6528267 Methods, kits and compositions pertaining to PNA molecular beacons 12 2001
6649349 In-situ methods for analyzing target sequences using linear beacons 4 2001
6770442 Methods for modulating the solubility of synthetic polymers 0 2001
6905824 Methods for determining organisms not requiring the separation of fixative or excess probe 0 2001
* 2003/0165,856 Methods for determining organisms not requiring the separation of fixative or excess probe 0 2001
7256275 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 5 2002
* 2003/0211,483 Methods for the enrichment of low-abundance polynucleotides 8 2002
* 2003/0073,106 Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices 44 2002
6949343 Methods, kits and compositions pertaining to PNA Molecular Beacons 1 2003
* 2003/0232,327 Methods, kits and compositions pertaining to PNA Molecular Beacons 0 2003
* 8017758 PNA oligomers, oligomer sets, methods and kits pertaining to the detection of Bacillus anthracis 2 2003
* 2004/0014,105 Methods for the enrichment of low-abundance polynucleotides 11 2003
7816501 Compositions comprising a linked acceptor moiety 0 2003
* 2009/0270,602 Compositions comprising a linked acceptor moiety 1 2003
* 2006/0014,191 Analog probe complexes 9 2005
* 2006/0292,586 ID-tag complexes, arrays, and methods of use thereof 8 2005
7674585 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 2 2006
7638279 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 1 2006
* 2008/0125,332 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation 0 2006
7884053 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7851155 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7745126 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 1 2006
7605253 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
7566420 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation 0 2006
* 2009/0163,381 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation 0 2006
* 2008/0085,837 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation 4 2006
* 2007/0105,145 Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation 0 2006
* 2008/0241,838 METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS 3 2007
* 2008/0193,940 SYSTEMS AND METHODS FOR DETECTING NUCLEIC ACIDS 2 2007
7892741 Methods, kits and compositions pertaining to linear beacons 1 2008
 
Q-RNA, INC. (2)
* 2006/0199,194 Methods of detection using immuno-Q-Amp technology 0 2005
* 2006/0024,736 Methods of detection employing immuno-Q-Amp technology 0 2005
 
ONCOLMMUNIN, INC. (2)
6893868 Homo-doubly labeled compositions for the detection of enzyme activity in biological samples 7 2000
7312302 Compositions for the detection of enzyme activity in biological samples and methods of use thereof 2 2001
 
WILLIAM MARSH RICE UNIVERSITY (1)
* 2011/0045,080 Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto 11 2010
 
MORPHOTEK, INC. (2)
7754450 Methods of generating high-production of antibodies from hybridomas created by in vitro immunization 2 2003
8445229 Methods of generating high-production of antibodies from hybridomas created by in vitro immunization 0 2010
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
6960457 Reversible immobilization of arginine-tagged moieties on a silicate surface 5 2000
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (6)
6472209 Using polyamide nucleic acid oligomers to engender a biological response 2 1997
6743627 Using polyamide nucleic acid oligomers to engender a biological response 1 1998
6989270 Using polyamide nucleic acid oligomers to engender a biological response 0 1998
6723560 Using polyamide nucleic acid oligomers to engender a biological response 1 1998
* 2003/0109,537 Methods and materials for treating bone conditions 11 2002
* 2004/0009,899 Treating dominant disorders 0 2002
 
DAKO DENMARK A/S (9)
* 6110676 Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays 130 1997
6962778 Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays 4 2000
* 2003/0124,521 Methods, kits and compositions for supressing the binding of detectable probes to non-target sequences in hybridization assays 3 2000
7306916 Methods for detecting chromosome aberrations 1 2005
* 2006/0078,904 Methods for detecting chromosome aberrations 0 2005
9297035 Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers 0 2009
9388456 Compositions and methods for performing a stringent wash step in hybridization applications 0 2009
9303287 Compositions and methods for RNA hybridization applications 0 2009
9309562 Compositions and methods for performing hybridizations with separate denaturation of the sample and probe 0 2010
 
The Research Foundation of State University of New York (3)
* 9150612 RNA targeting compounds and methods for making and using same 0 2008
* 2008/0227,213 RNA targeting compounds and methods for making and using same 5 2008
9260476 RNA targeting compounds and methods for making and using same 0 2013
 
Obe Therapy Biotechnology S.A.S. (1)
* 2007/0298,025 Pharmaceutical Compositions and Methods for Reducing Body Fat 6 2007
 
ARC MEDICAL DEVICES, INC. (1)
* 2011/0104,295 PHARMACEUTICAL COMPOSITIONS AND METHODS RELATING TO INHIBITING FIBROUS ADHESIONS OR INFLAMMATORY DISEASE USING LOW SULPHATE FUCANS 1 2010
 
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (6)
7429489 Methods of controlling proliferation and differentiation of stem and progenitor cells 1 2004
* 2005/0118,150 Methods of controlling proliferation and differentiation of stem and progenitor cells 3 2004
7312078 Methods of controlling proliferation and differentiation of stem and progenitor cells 4 2005
* 2005/0214,262 Methods of controlling proliferation and differentiation of stem and progenitor cells 3 2005
7855075 Methods of controlling proliferation and differentiation of stem and progenitor cells 0 2008
8202724 Methods of controlling proliferation and differentiation of stem and progenitor cells 0 2010
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
7833729 Method for detecting endometriosis in a patient sample 0 2009
 
CHILDRENS HOSPITAL LOS ANGELES (2)
7951785 NFIA in glial fate determination, glioma therapy and astrocytoma treatment 0 2008
* 2009/0087,434 NFIA IN GLIAL FATE DETERMINATION, GLIOMA THERAPY AND ASTROCYTOMA TREATMENT 0 2008
 
MYCOLOGICS, INC. (1)
6716625 Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use 0 2000
 
CHANG GUNG UNIVERSITY (2)
7803543 Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe 1 2007
* 2008/0176,226 METHODS AND KITS FOR THE DETECTION OF NUCLEOTIDE MUTATIONS USING PEPTIDE NUCLEIC ACID AS BOTH PCR CLAMP AND SENSOR PROBE 5 2007
 
CATERPILLAR INC. (1)
* 2009/0288,392 Engine system having particulate reduction device and method 5 2008
 
SWIFT BIOSCIENCES, INC. (1)
8889350 Methods and compositions for isolating polynucleotides 0 2011
 
VANDERBILT UNIVERSITY (4)
6312956 Nuclear targeted peptide nucleic acid oligomer 23 1999
6623966 Nuclear targeted peptide nucleic acid oligomer 4 2001
9562853 Nonaqueous backscattering interferometric methods 0 2012
9273949 Backscattering interferometric methods 0 2013
 
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (1)
* 2003/0151,317 Brushless motor and method of manufacturing the brushless motor 1 2003
 
RECOMBINETICS, INC. (2)
9074224 Methods and compositions for targeted gene modification 0 2010
* 2011/0059,160 METHODS AND COMPOSITIONS FOR TARGETED GENE MODIFICATION 6 2010
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (10)
* 2006/0008,464 Histone conjugates and uses thereof 0 2003
* 2006/0009,378 Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases 1 2005
7534605 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 3 2005
* 2006/0019,340 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 3 2005
8067573 Nucleic acid agents for downregulating H19 and methods of using same 0 2006
* 2009/0143,321 NUCLEIC ACID AGENTS FOR DOWNREGULATING H19 AND METHODS OF USING SAME 1 2006
8067574 Nucleic acid agents for downregulating H19, and methods of using same 1 2008
7928083 H19 silencing nucleic acid agents for treating rheumatoid arthritis 0 2008
* 2010/0196,403 ANTIBODY CONJUGATES FOR CIRCUMVENTING MULTI-DRUG RESISTANCE 0 2008
8193311 CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 0 2011
 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (21)
7070928 Evolving new molecular function 25 2002
* 2003/0113,738 Evolving new molecular function 36 2002
7183054 Assay for identifying biological targets of polynucleotide-binding compounds 0 2003
* 2004/0248,100 Assay for identifying biological targets of polynucleotide-binding compounds 1 2003
7491494 Evolving new molecular function 24 2003
* 2004/0180,412 Evolving new molecular function 12 2003
7557068 Evolving new molecular function 15 2003
7122549 Saframycins, analogues and uses thereof 0 2004
7771935 Evolving new molecular function 15 2004
7223545 Evolving new molecular function 20 2004
* 2005/0170,376 Evolving new molecular function 19 2004
* 2005/0142,583 Evolving new molecular function 10 2004
* 2005/0042,669 Evolving new molecular function 24 2004
7998904 Evolving new molecular function 11 2005
7442160 Evolving new molecular function 15 2005
* 2005/0233,381 Evolving new molecular 11 2005
* 2005/0227,281 Evolving new molecular function 2 2005
8017323 Free reactant use in nucleic acid-templated synthesis 2 2006
* 2006/0223,086 Free reactant use in nucleic acid-templated synthesis 10 2006
8206914 Evolving new molecular function 0 2010
* 2011/0190,141 Evolving New Molecular Function 2 2010
* Cited By Examiner