Viscous suspensions of controlled-release drug particles
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United States of America Patent
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Jul 30, 1996
Grant Date -
N/A
app pub date -
Sep 30, 1994
filing date -
Mar 30, 1992
priority date (Note) -
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Abstract
Controlled-release particles containing biologically effective agents such as therapeutic drugs and local anesthetics are suspended in a liquid suspending vehicle which has an elevated viscosity, the viscosity being substantially higher than that of water. Preferred vehicles are non-aqueous liquids and aqueous media which contain a dissolved polymer to increase the viscosity of the vehicle. Regardless of the composition of the media, however, the increased viscosity permits the use of particles of a relatively large size without a loss of suspension stability or localized application. The large particles offer the advantage of a longer release profile, and thus more prolonged activity of the agent.
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