Backbone modified oligonucleotide analogs and solid phase synthesis thereof
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United States of America Patent
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Jul 30, 1996
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app pub date -
Dec 28, 1993
filing date -
Jul 27, 1990
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Abstract
Compounds and methods for preparing oligonucleotide analogs are provided. In preferred embodiments, the methods involve solid-phase coupling of synthons bearing either 3'-electrophillic groups and 5'-nucleophilic groups or 5'-electrophillic groups and 3'-nucleophilic groups to form neutral, achiral oligomers.
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