DNA ligands of thrombin
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United States of America Patent
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Aug 6, 1996
Issued Date -
N/A
app pub date -
Mar 28, 1994
filing date -
Jun 11, 1990
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Abstract
Methods are described for the identification of nucleic acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for EXponential Enrichment) method for identfying and preparing DNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the DNA ligands identified. The modified DNA ligands to thrombin exhibit increased in vivo stability.
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