Method and formulation of stimulating nitric oxide synthesis
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United States of America Patent
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Aug 6, 1996
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N/A
app pub date -
Oct 5, 1994
filing date -
Oct 5, 1994
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Abstract
A therapeutic mixture comprising a mixture of L-arginine and an agonist of nitric oxide synthase, namely nitroglycerin, is disclosed for the treatment of diseases related to vasoconstriction, wherein the vasoconstriction is relieved by stimulating the constitutive form of nitric oxide synthase (cNOS) to produce native nitric oxide (NO). The native NO having superior beneficial effect when compared to exogenous NO produced by a L-arginine independent pathway in terms of the ability to reduce clinical endpoints and mortality.
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