Solid phase and combinatorial synthesis of compounds on a solid support
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United States of America Patent
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Aug 13, 1996
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app pub date -
Dec 2, 1993
filing date -
Sep 14, 1992
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Abstract
Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, .beta.-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.
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