Production of antibodies from transgenic animals
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United States of America Patent
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Aug 13, 1996
Issued Date -
N/A
app pub date -
Aug 5, 1994
filing date -
Oct 12, 1988
priority date (Note) -
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Abstract
Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange to encode a repertoire of immunoglobulins, i.e. derived from a different animal source. For example, wholly human immunoglobulins may be produced from a transgenic mouse, possibly in response to an immunogen subsequently introduced to the mouse.
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