Preparation and use of novel injectable RES avoiding inorganic particles for medical application
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United States of America Patent
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Aug 20, 1996
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app pub date -
Jul 20, 1994
filing date -
Dec 22, 1989
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Abstract
Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid)--poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.
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