US Patent No: 5,548,065
Number of patents in Portfolio can not be more than 2000
Tyrosine kinase receptor human flk-2-specific antibodies
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Aug 20, 1996
Issued date -
Oct 31, 1994
filing date -
08/252,517
serial no -
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Abstract
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,185,438 Nucleic acids encoding hencatoporetic stem cell receptor flk-2 | 66 | 1991 | |
| 5,283,354 Nucleic acids encoding hematopoietic stem cells receptors flk-1 | 56 | 1992 | |
| 5,270,458 Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 | 51 | 1992 | |
| 5,367,057 Tyrosine kinase receptor flk-2 and fragments thereof | 22 | 1993 | |
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| 5,061,620 Human hematopoietic stem cell | 216 | 1990 | |