Combination therapy for the treatment of estrogen-sensitive disease

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United States of America Patent

PATENT NO 5550107
SERIAL NO

07785890

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH agonist, e.g. [D-Trp.sup.6, des-Gly-NH.sub.2.sup.10 ]LHRH ethylamide or antagonist) as part of a combination therapy comprising administering an antiestrogen together with at least one compound selected from the group consisting of an androgen, a progestin, at least one inhibitor of sex steroid formation, especially 17.beta.-hydroxysteroid dehydrogenase and aromatase activity, at least one inhibitor of prolactin secretion, one inhibitor of growth hormone secretion and one inhibitor of ACTH secretion. Pharmaceutical compositions useful for such treatment and pharmaceutical kits containing such composition are disclosed.

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Patent Owner(s)

Patent OwnerAddress
ENDORECHERCHE INCQUEBEC CAN QUEBEC

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Inventor Name Address # of filed Patents Total Citations
Labrie, Fernand Quebec, CA 124 2037

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