Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
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United States of America Patent
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Aug 27, 1996
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app pub date -
Nov 3, 1994
filing date -
Jul 11, 1984
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Abstract
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.
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