Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent
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United States of America Patent
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Sep 3, 1996
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N/A
app pub date -
Aug 12, 1994
filing date -
Jul 2, 1993
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Abstract
Encapsulated gas microspheres useful as an ultrasonic imaging agent are made by: mixing an aqueous solution of a heat-denaturable protein with a gas, and passing the gas-solution mixture through a mill whereby the mixture is emulsified near the denaturation temperature of the protein and subjected to mechanical shearing and cavitation which causes the formation of gas bubbles in the 0.1 to 10 micron range, and the protein to locally denature and deposit at the gas-liquid interface to form the encapsulated microspheres.
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