Solid depot drug form
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United States of America Patent
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Sep 3, 1996
Issued Date -
N/A
app pub date -
Sep 23, 1993
filing date -
Nov 23, 1991
priority date (Note) -
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status (Latency Note)
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Abstract
A solid depot drug form produced by melt extrusion at from 50.degree. to 200.degree. C. and continuous shaping of a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutical active ingredient with a polymer melt of the following composition: a) at least 6% by weight, based on the complete depot form, of at least one water-insoluble poly(meth) acrylate with a glass transition temperature Tg in the range from -60.degree. to 180.degree. C., b) a water-soluble hydroxyalkylcellulose or hydroxy-alkylmethylcellulose with 2 or 3 carbons in the hydroxyalkyl, or an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or a mixture of the two in the ratio a):b) =5:95 to 95:5, and c) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries.
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