Plasmids and process for producing recombinant desulphatohirudin HV-1 peptides
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Sep 3, 1996
Grant Date -
N/A
app pub date -
Apr 9, 1993
filing date -
Apr 9, 1992
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms. Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with isolated promoters and signal sequences, subsequently the expression/secretion cassettes comprising the foregoing elements were inserted into plasmid DNAs allowing the cultivation of cells under selective culture conditions. E. coli, Saccharomyces and Streptomyces species were transformed with the said recombinant plasmids to biosynthesize the thrombin inhibitor desulphatohirudin HV-1 which was then isolated and identified. The thus-produced desulphatohirudin can be used to inhibit blood coagulation.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully