MDC proteins and DNAS encoding the same
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United States of America Patent
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Sep 3, 1996
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N/A
app pub date -
May 13, 1994
filing date -
May 14, 1993
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Abstract
The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ('MDC protein') encoded by the gene, a method for the diagnosis of cancer by using an antibody combinable to the protein, and others. A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as antigen.
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