Inhibiting the development of tolerance to and/or dependence on an addictive substance
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United States of America Patent
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Sep 17, 1996
Issued Date -
N/A
app pub date -
May 19, 1994
filing date -
Jan 28, 1993
priority date (Note) -
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Abstract
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
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