Process for the enzymatic preparation of GRF(1-44)NH.sub.2
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United States of America Patent
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Oct 8, 1996
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N/A
app pub date -
Jun 5, 1995
filing date -
Dec 10, 1990
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Expired
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Abstract
GRF(1-44)-NH.sub.2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH.sub.2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides an economical pathway to the clinically important GRF(1-44)-NH.sub.2 compound.
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