Sesquiterpenes, their preparation and their use as inhibitors acting on the gaba-benzodiazepine receptor
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United States of America Patent
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Oct 15, 1996
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N/A
app pub date -
Aug 29, 1995
filing date -
Dec 22, 1992
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Abstract
Sesquiterpenes obtainable from the fungal strain Acremonium strictum XO6/15/458, and phannaceutically and veterinarily acceptable salts thereof, are inhibitors of the binding of benzodiazepine to the GABA-benzodiazepine-Cl ionophore receptor complex. These compounds are prepared by (i) fermenting, in a source of carbon, nitrogen and inorganic salts, fungal strain XO6/15/458 (IMI 354451) or a mutant thereof which produces the sesquiterpenes, (ii) isolating the sesquiterpenes from the fermentation medium; and (iii) if desired, converting the sesquiterpene into a pharmaceutically or veterinarily acceptable salt.
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