Method for inhibiting angiogenesis using heparinase
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United States of America Patent
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Oct 22, 1996
Issued Date -
N/A
app pub date -
May 1, 1995
filing date -
Nov 17, 1993
priority date (Note) -
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Abstract
Pharmaceutical compositions for delivering an effective dose to a desired site of a heparinase. These compositions are based on the discovery that heparinase alone can inhibit angiogenesis. The effective dosage is dependent not only on the heparinase, but also on the method and means of delivery, which can be localized or systemic. For example, in some applications, as in the treatment of psoriasis or diabetic retinopathy, the inhibitor is delivered in a topical ophthalmic carrier. In other applications, as in the treatment of solid tumors, the inhibitor is delivered by means of a biodegradable, polymeric implant.
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