Use of isolated domains of type IV collagen to modify cell and tissue interactions

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United States of America Patent

PATENT NO 5567609
SERIAL NO

08268969

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Abstract

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The instant invention demonstrates that the 7S and NC1 domains of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF KANSAS MEDICAL CENTER3901 RAINBOW BOULEVARD KANSAS CITY KS 66160-7702

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hudson, Billy G Lenexa, KS 47 554
Sarras, Jr Michael P Kansas City, KS 13 76

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