Texaphyrins and uses thereof
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United States of America Patent
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Oct 22, 1996
Issued Date -
N/A
app pub date -
Sep 21, 1994
filing date -
Mar 6, 1989
priority date (Note) -
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Abstract
A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
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