Pharmaceutically active agents that impede amyloid formation in vivo
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United States of America Patent
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Oct 22, 1996
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app pub date -
Jun 27, 1994
filing date -
Aug 27, 1986
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Abstract
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10.sup.-5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.
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