Gaseous microparticles as ultrasound contrast agents
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United States of America Patent
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Oct 29, 1996
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Jun 3, 1991
priority date (Note) -
Expired
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Abstract
This invention relates to ultrasound contrast agents in the form of microparticles comprising a biotolerable matrix (e.g. of a carbohydrate or an X-ray contrast agent) in association with a gas or a precursor therefor. The contrast agents are stabilized to enhance their in vivo stability and/or echogenicity by covalently modifying the structure of the matrix, e.g. to introduce crosslinking groups or to attach lipophilic groups and/or molecules. The covalent moieties may include biodegradable linkages to assist rapid subsequent elimination of the contrast agents from the system.
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