Process for the preparation of microballs and microballs thus obtained
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United States of America Patent
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Oct 29, 1996
Issued Date -
N/A
app pub date -
May 16, 1994
filing date -
May 15, 1993
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A method of making microballs is disclosed. An active ingredient, a biocompatible polymer and a supporting phase, such as silicone oil, are stirred at a temperature above the Tg of the polymer and below the temperature at which any of the ingredients vaporizes or degrades. Stirring is continued until microballs of the desired diameter are formed, whereafter the mixture is cooled and the microballs are separated from the supporting phase. The microballs are substantially spherical, substantially smooth on their external surface and have substantially no active ingredient on their external surface.
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