US Patent No: 5,569,468

Number of patents in Portfolio can not be more than 2000

Vaccine delivery system for immunization, using biodegradable polymer microspheres

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A controlled release oral formulation, for human vaccines, are formed in microspherical form. The vaccine is suspended in a polymer matrix. The polymer matrix is formed from at least two highly water soluble biodegradable polymers, selected for example from starch, crosslinked starch, ficoll, polysucrose, polyvinyl alcohol, gelatine, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-ethyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxymethyl cellulose, cellulose acetate, sodium alginate, polymaleic anhydride esters, polyortho esters, polyethyteneimine, polyethylene glycol, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide,poly(1,3 bis(p-carboxyphenoxy) propane-co-sebacic anhydride, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene. The microspheres are coated with a (d,1 lactide-glycolide) copolymer. The coating makes the microspheres more resistant to enzymatic degradation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CENTRUM BIOTECHNOLOGIES INC.BURLINGTON ONT, CA2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Modi, Pankaj Ancaster, CA 51 620

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
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WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED (1)
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CENTRUM BIOTECHNOLOGIES INC. (1)
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UNIVERSITY OF WASHINGTON (1)
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Syntex (U.S.A.) Inc. (1)
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Debio Recherche Pharmaceutique S.A. (4)
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BIOTEX, INC. (1)
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National Starch and Chemical Corporation (1)
* 4,755,397 Starch based particulate encapsulation process 40 1986
 
LA REGION WALLONNE (1)
* 4,897,267 Microparticles comprising a biodegradable polymer controlling the release of an antimalaria active principle, pharmaceutical compositions comprising it and process for its preparation 22 1988
 
AKZO N.V. (1)
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IMPERIAL CHEMICAL INDUSTRIES PLC (1)
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EASTMAN CHEMICAL COMPANY (1)
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TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
* 5,126,145 Controlled release tablet containing water soluble medicament 115 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
MERCK SHARP & DOHME CORP. (1)
* 6,251,678 Human papillomavirus vaccine formulations 15 2000
 
Epitopix, LLC (1)
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SCIL TECHNOLOGY GMBH (1)
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SUPRATEK PHARMA INC. (1)
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PIONEER SURGICAL TECHNOLOGY, INC. (3)
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SCIMED LIFE SYSTEMS, INC. (1)
7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 1 2006
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (3)
6,193,951 Microparticles useful as ultrasonic contrast agents 28 1998
6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
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BAXTER INTERNATIONAL INC. (3)
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SOUTHERN BIOSYSTEMS, INC. (1)
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DURECT CORPORATION (1)
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STRYKER NV OPERATIONS LIMITED (1)
8,101,197 Forming coils 0 2005
 
BOSTON SCIENTIFIC SCIMED, INC. (33)
7,094,369 Processes for manufacturing polymeric microspheres 18 2002
7,588,780 Embolization 3 2002
7,462,366 Drug delivery particle 32 2002
7,131,997 Tissue treatment 25 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 14 2003
7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 7 2003
8,012,454 Embolization 2 2003
7,588,825 Embolic compositions 3 2003
7,736,671 Embolization 2 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 7 2004
7,976,823 Ferromagnetic particles and methods 0 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 1 2005
7,727,555 Particles 3 2005
7,963,287 Tissue-treatment methods 13 2005
8,007,509 Coil assemblies, components and methods 12 2005
7,501,179 Block copolymer particles 4 2005
7,947,368 Block copolymer particles 0 2006
8,152,839 Embolic coils 1 2006
7,611,542 Tissue treatment 6 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 10 2007
7,666,333 Embolization 2 2007
7,951,402 Drug delivery particle 0 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 18 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 0 2010
8,394,400 Bulking agent 1 2010
8,430,105 Tissue-treatment methods 0 2011
8,273,324 Embolization 0 2011
8,586,071 Bulking agents 0 2013
 
WILLIAM MARSH RICE UNIVERSITY (1)
8,986,737 Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth 0 2008
* Cited By Examiner