US Patent No: 5,569,468

Number of patents in Portfolio can not be more than 2000

Vaccine delivery system for immunization, using biodegradable polymer microspheres

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A controlled release oral formulation, for human vaccines, are formed in microspherical form. The vaccine is suspended in a polymer matrix. The polymer matrix is formed from at least two highly water soluble biodegradable polymers, selected for example from starch, crosslinked starch, ficoll, polysucrose, polyvinyl alcohol, gelatine, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-ethyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxymethyl cellulose, cellulose acetate, sodium alginate, polymaleic anhydride esters, polyortho esters, polyethyteneimine, polyethylene glycol, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide,poly(1,3 bis(p-carboxyphenoxy) propane-co-sebacic anhydride, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene. The microspheres are coated with a (d,1 lactide-glycolide) copolymer. The coating makes the microspheres more resistant to enzymatic degradation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CENTRUM BIOTECHNOLOGIES INC.BURLINGTON ONT, CA2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Modi, Pankaj 1928 Main St. W. Apt. 608, Hamilton, CA 45 769

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
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WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED (1)
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CENTRUM BIOTECHNOLOGIES INC. (1)
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University of Washington (1)
* 4,622,244 Process for preparation of microcapsules 104 1984
 
SYNTEX (U.S.A.) INC. (1)
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DEBIO RECHERCHE PHARMACEUTIQUE S.A. (4)
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* 5,134,122 Method for preparing a pharmaceutical composition in the form of microparticles 48 1990
* 5,225,205 Pharmaceutical composition in the form of microparticles 53 1992
 
BIOTEX, INC. (1)
* 4,568,559 Composite core coated microparticles and process of preparing same 105 1984
 
Thomas F. Roland NATIONAL STARCH AND CHEMICAL COMPANY P.O. Box 6500 (1)
* 4,755,397 Starch based particulate encapsulation process 41 1986
 
La Region Wallonne (1)
* 4,897,267 Microparticles comprising a biodegradable polymer controlling the release of an antimalaria active principle, pharmaceutical compositions comprising it and process for its preparation 22 1988
 
AKZO N.V. (1)
* 4,645,664 Microporous powder form polylactides 10 1985
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
* 4,526,938 Continuous release formulations 294 1983
 
EASTMAN CHEMICAL COMPANY (1)
* 5,025,004 Water-dispersible polymeric compositions 45 1990
 
TCF NATIONAL BANK (1)
* 5,126,145 Controlled release tablet containing water soluble medicament 123 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
MERCK SHARP & DOHME CORP. (1)
* 6,251,678 Human papillomavirus vaccine formulations 18 2000
 
Other [Check patent profile for assignment information] (1)
* 2005/0013,780 Hollow microspheres with controlled fragility for medical use 1 2004
 
EPITOPIX LLC (2)
6,682,754 Ovo delivery of an immunogen containing implant 34 1999
* 2007/0098,733 In ovo delivery of an immunogen containing implant 15 2003
 
THERAJECT, INC. (1)
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POINT BIOMEDICAL CORPORATION (3)
* 2003/0215,394 Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream 12 2002
* 2004/0185,108 Method of preparing gas-filled polymer matrix microparticles useful for delivering drug 1 2003
* 2005/0113,697 Method of imaging lymphatic system using nanocapsule compositions 18 2004
 
SCIL TECHNOLOGY GMBH (1)
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Supratek Pharma Inc. (1)
6,359,054 Polynucleotide compositions for intramuscular administration 21 1999
 
PIONEER SURGICAL TECHNOLOGY, INC. (4)
8,053,423 Method of preparing cross-linked bioactive hydrogel matrices 12 2010
* 2010/0226,961 CROSS-LINKED BIOACTIVE HYDROGEL MATRICES 6 2010
8,664,202 Cross-linked bioactive hydrogel matrices 0 2011
8,957,050 Bone implant materials comprising cross-linked bioactive hydrogel matrices 0 2013
 
ALBANY MEDICAL COLLEGE (1)
6,524,586 Enhancement of oligomeric viral immunogenicity 2 2001
 
POWDERJECT VACCINES, INC. (1)
* 2004/0109,874 Induction of mucosal immunity by vaccination via the skin route 4 2003
 
SCIMED LIFE SYSTEMS, INC. (1)
7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 4 2006
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (5)
6,193,951 Microparticles useful as ultrasonic contrast agents 37 1998
6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
* 2006/0013,771 Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging 0 2005
* 2006/0241,466 Hollow microspheres with controlled fragility for medical use 4 2006
8,486,444 Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system 0 2011
 
STRYKER EUROPEAN HOLDINGS I, LLC (1)
8,101,197 Forming coils 1 2005
 
BAXTER INTERNATIONAL INC. (3)
6,090,925 Macromolecular microparticles and methods of production and use 132 1996
5,981,719 Macromolecular microparticles and methods of production and use 121 1998
6,268,053 Macromolecular microparticles and methods of production and use 98 2000
 
SOUTHERN BIOSYSTEMS, INC. (1)
8,263,108 Zero-order prolonged release coaxial implants 0 2002
 
DURECT CORPORATION (1)
8,889,174 Zero-order prolonged release coaxial implants 0 2012
 
BOSTON SCIENTIFIC SCIMED, INC. (34)
7,094,369 Processes for manufacturing polymeric microspheres 22 2002
7,588,780 Embolization 5 2002
7,462,366 Drug delivery particle 34 2002
7,131,997 Tissue treatment 33 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 17 2003
7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 9 2003
8,012,454 Embolization 3 2003
7,588,825 Embolic compositions 5 2003
7,736,671 Embolization 5 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 10 2004
7,976,823 Ferromagnetic particles and methods 1 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 2 2005
7,727,555 Particles 5 2005
7,963,287 Tissue-treatment methods 20 2005
8,007,509 Coil assemblies, components and methods 13 2005
7,501,179 Block copolymer particles 5 2005
7,947,368 Block copolymer particles 1 2006
8,152,839 Embolic coils 2 2006
7,611,542 Tissue treatment 10 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 33 2007
7,666,333 Embolization 4 2007
7,951,402 Drug delivery particle 3 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 31 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 1 2010
8,394,400 Bulking agent 1 2010
8,430,105 Tissue-treatment methods 1 2011
8,273,324 Embolization 0 2011
8,586,071 Bulking agents 0 2013
9,283,035 Tissue-treatment methods 0 2013
 
HORIZON TECHNOLOGY FUNDING COMPANY LLC (1)
* 2004/0086,459 Microparticles useful as ultrasonic contrast agents 3 2003
 
WILLIAM MARSH RICE UNIVERSITY (3)
* 2004/0131,681 Antibiotic microspheres for treatment of infections and osteomyelitis 4 2003
8,986,737 Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth 0 2008
* 2009/0148,497 Antibiotic Microspheres for Treatment and Prevention Of Osteomyelitis and Enhancement of Bone Regrowth 1 2008
* Cited By Examiner