US Patent No: 5,569,468

Number of patents in Portfolio can not be more than 2000

Vaccine delivery system for immunization, using biodegradable polymer microspheres

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Abstract

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A controlled release oral formulation, for human vaccines, are formed in microspherical form. The vaccine is suspended in a polymer matrix. The polymer matrix is formed from at least two highly water soluble biodegradable polymers, selected for example from starch, crosslinked starch, ficoll, polysucrose, polyvinyl alcohol, gelatine, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-ethyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxymethyl cellulose, cellulose acetate, sodium alginate, polymaleic anhydride esters, polyortho esters, polyethyteneimine, polyethylene glycol, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide,poly(1,3 bis(p-carboxyphenoxy) propane-co-sebacic anhydride, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene. The microspheres are coated with a (d,1 lactide-glycolide) copolymer. The coating makes the microspheres more resistant to enzymatic degradation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CENTRUM BIOTECHNOLOGIES INC.BURLINGTON ONT, CA2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Modi, Pankaj Ancaster, CA 49 558

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Debio Recherche Pharmaceutique S.A. (4)
5,192,741 Sustained and controlled release of water insoluble polypeptides 106 1988
5,187,150 Polyester-based composition for the controlled release of polypeptide medicinal substances 18 1990
5,134,122 Method for preparing a pharmaceutical composition in the form of microparticles 37 1990
5,225,205 Pharmaceutical composition in the form of microparticles 50 1992
 
AKZO N.V. (1)
4,645,664 Microporous powder form polylactides 10 1985
 
BIOTEX, INC. (1)
4,568,559 Composite core coated microparticles and process of preparing same 96 1984
 
CENTRUM BIOTECHNOLOGIES INC. (1)
5,417,982 Controlled release of drugs or hormones in biodegradable polymer microspheres 90 1994
 
EASTMAN CHEMICAL COMPANY (1)
5,025,004 Water-dispersible polymeric compositions 44 1990
 
ETHICON, INC. (1)
4,328,204 Absorbable polymer-drug compounds and method for making same 27 1977
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
4,526,938 Continuous release formulations 253 1983
 
LA REGION WALLONNE (1)
4,897,267 Microparticles comprising a biodegradable polymer controlling the release of an antimalaria active principle, pharmaceutical compositions comprising it and process for its preparation 22 1988
 
National Starch and Chemical Corporation (1)
4,755,397 Starch based particulate encapsulation process 40 1986
 
Syntex (U.S.A.) Inc. (1)
4,675,189 Microencapsulation of water soluble active polypeptides 302 1985
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 106 1990
 
The United States of America as represented by the Secretary of Agriculture (1)
4,272,398 Microencapsulation process 104 1979
 
UNIVERSITY OF WASHINGTON (1)
4,622,244 Process for preparation of microcapsules 96 1984
 
WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED (1)
4,904,479 Drug delivery system 175 1987
 
Other [Check patent profile for assignment information] (1)
4,832,686 Method for administering interleukin-2 103 1986

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (33)
7,094,369 Processes for manufacturing polymeric microspheres 18 2002
7,588,780 Embolization 3 2002
7,462,366 Drug delivery particle 30 2002
7,131,997 Tissue treatment 23 2002
7,883,490 Mixing and delivery of therapeutic compositions 3 2002
7,053,134 Forming a chemically cross-linked particle of a desired shape and diameter 14 2003
7,449,236 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 7 2003
8,012,454 Embolization 2 2003
7,588,825 Embolic compositions 3 2003
7,736,671 Embolization 2 2004
8,173,176 Embolization 1 2004
7,311,861 Embolization 6 2004
7,976,823 Ferromagnetic particles and methods 0 2004
8,425,550 Embolic coils 0 2004
7,858,183 Particles 1 2005
7,727,555 Particles 2 2005
7,963,287 Tissue-treatment methods 8 2005
8,007,509 Coil assemblies, components and methods 7 2005
7,501,179 Block copolymer particles 4 2005
7,947,368 Block copolymer particles 0 2006
8,152,839 Embolic coils 0 2006
7,611,542 Tissue treatment 6 2006
7,507,772 Forming a chemically cross-linked particle of a desired shape and diameter 0 2007
8,414,927 Cross-linked polymer particles 5 2007
7,666,333 Embolization 2 2007
7,951,402 Drug delivery particle 0 2008
7,842,377 Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient 12 2008
7,964,123 Embolization 0 2010
8,216,612 Embolization 0 2010
8,394,400 Bulking agent 1 2010
8,430,105 Tissue-treatment methods 0 2011
8,273,324 Embolization 0 2011
8,586,071 Bulking agents 0 2013
 
BAXTER INTERNATIONAL INC. (3)
6,090,925 Macromolecular microparticles and methods of production and use 100 1996
5,981,719 Macromolecular microparticles and methods of production and use 91 1998
6,268,053 Macromolecular microparticles and methods of production and use 83 2000
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (3)
6,193,951 Microparticles useful as ultrasonic contrast agents 27 1998
6,776,761 Hollow microspheres with controlled fragility for medical use 2 2002
8,486,444 Nanobubbles useful as an ultrasonic contrast agent for the lymphatic system 0 2011
 
PIONEER SURGICAL TECHNOLOGY, INC. (2)
8,053,423 Method of preparing cross-linked bioactive hydrogel matrices 10 2010
8,664,202 Cross-linked bioactive hydrogel matrices 0 2011
 
ALBANY MEDICAL COLLEGE (1)
6,524,586 Enhancement of oligomeric viral immunogenicity 2 2001
 
EPITOPIX LLC (1)
6,682,754 Ovo delivery of an immunogen containing implant 25 1999
 
MERCK SHARP & DOHME CORP. (1)
6,251,678 Human papillomavirus vaccine formulations 15 2000
 
SCIMED LIFE SYSTEMS, INC. (1)
7,288,319 Forming a chemically cross-linked particle of a desired shape and diameter 1 2006
 
SOUTHERN BIOSYSTEMS, INC. (1)
8,263,108 Zero-order prolonged release coaxial implants 0 2002
 
STRYKER NV OPERATIONS LIMITED (1)
8,101,197 Forming coils 0 2005
 
SUPRATEK PHARMA INC. (1)
6,359,054 Polynucleotide compositions for intramuscular administration 16 1999
 
Other [Check patent profile for assignment information] (1)
8,889,174 Zero-order prolonged release coaxial implants 0 2012