US Patent No: 5,569,468
Number of patents in Portfolio can not be more than 2000
Vaccine delivery system for immunization, using biodegradable polymer microspheres
Stats
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Oct 29, 1996
Issued date -
Feb 17, 1994
filing date -
08/197,754
serial no -
In Force
status
Importance
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Abstract
A controlled release oral formulation, for human vaccines, are formed in microspherical form. The vaccine is suspended in a polymer matrix. The polymer matrix is formed from at least two highly water soluble biodegradable polymers, selected for example from starch, crosslinked starch, ficoll, polysucrose, polyvinyl alcohol, gelatine, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl-ethyl cellulose, hydroxypropyl-methyl cellulose, sodium carboxymethyl cellulose, cellulose acetate, sodium alginate, polymaleic anhydride esters, polyortho esters, polyethyteneimine, polyethylene glycol, methoxypolyethylene glycol, ethoxypolyethylene glycol, polyethylene oxide,poly(1,3 bis(p-carboxyphenoxy) propane-co-sebacic anhydride, N,N-diethylaminoacetate, block copolymers of polyoxyethylene and polyoxypropylene. The microspheres are coated with a (d,1 lactide-glycolide) copolymer. The coating makes the microspheres more resistant to enzymatic degradation.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,192,741 Sustained and controlled release of water insoluble polypeptides | 96 | 1988 | |
| 5,187,150 Polyester-based composition for the controlled release of polypeptide medicinal substances | 16 | 1990 | |
| 5,134,122 Method for preparing a pharmaceutical composition in the form of microparticles | 28 | 1990 | |
| 5,225,205 Pharmaceutical composition in the form of microparticles | 38 | 1992 | |
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| 4,645,664 Microporous powder form polylactides | 10 | 1985 | |
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| 4,568,559 Composite core coated microparticles and process of preparing same | 87 | 1984 | |
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| 5,417,982 Controlled release of drugs or hormones in biodegradable polymer microspheres | 76 | 1994 | |
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| 5,025,004 Water-dispersible polymeric compositions | 44 | 1990 | |
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| 4,328,204 Absorbable polymer-drug compounds and method for making same | 27 | 1977 | |
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| 4,526,938 Continuous release formulations | 215 | 1983 | |
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| 4,897,267 Microparticles comprising a biodegradable polymer controlling the release of an antimalaria active principle, pharmaceutical compositions comprising it and process for its preparation | 22 | 1988 | |
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| 4,755,397 Starch based particulate encapsulation process | 38 | 1986 | |
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| 4,675,189 Microencapsulation of water soluble active polypeptides | 276 | 1985 | |
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| 5,126,145 Controlled release tablet containing water soluble medicament | 96 | 1990 | |
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| 4,272,398 Microencapsulation process | 94 | 1979 | |
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| 4,622,244 Process for preparation of microcapsules | 90 | 1984 | |
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| 4,904,479 Drug delivery system | 158 | 1987 | |
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| 4,832,686 Method for administering interleukin-2 | 76 | 1986 | |