US Patent No: 5,571,568

Number of patents in Portfolio can not be more than 2000

Multilayered bioelectronic sensors

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Abstract

Bioelectronic sensors are provided employing a thin surfactant polymeric electrically conducting layer to which may be bound members of specific binding pairs. Binding of an analyte or a reagent to the specific binding pair member layer may change the electrical, optical, or structural properties of the layer for measurement of analyte. The change in the polymeric layer provides for a sensitive measurement.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BIOCIRCUITS CORPORATIONSUNNYVALE, CA14

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guion, Todd Felton, CA 3 265
Ribi, Hans O San Mateo, CA 56 998
Shafer, Paul T Burlingame, CA 3 244

Cited Art

Patent Info (Count) # Cites Year
 
ALLIED SIGNAL (1)
4,824,529 Lipid membrane-based device 17 1987
 
BIOCIRCUITS CORPORATION (1)
5,491,097 Analyte detection with multilayered bioelectronic conductivity sensors 155 1994
 
BIOCIRCUITS, INC. A CORPORATION OF DELAWARE (1)
4,859,538 Novel lipid-protein compositions and articles and methods for their preparation 42 1986
 
BOSTON BIOMEDICAL RESEARCH INSTITUTE (1)
4,444,878 Bispecific antibody determinants 96 1981
 
COMMISSARIAT A L'ENERGIE ATOMIQUE (1)
4,632,800 Process for producing a thin film having at least one monomolecular layer of non-amphiphilic molecules 21 1985
 
MARCONI UK INTELLECTUAL PROPERTY LTD. (1)
4,857,273 Biosensors 114 1986
 
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (1)
4,960,722 Sensor using a field effect transistor and method of fabricating the same 10 1989
 
MILES LABORATORIES, INC. (1)
4,560,534 Polymer catalyst transducers 154 1983
 
MOLECULAR DEVICES CORPORATION (1)
4,490,216 Lipid membrane electroanalytical elements and method of analysis therewith 80 1984
 
OHMICRON TECHNOLOGY, INC. (1)
4,444,892 Analytical device having semiconductive organic polymeric element associated with analyte-binding substance 177 1982
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,489,133 Two-dimensional crystallization technique 25 1982
 
UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION, OF TORONTO, THE, METROPOLITAN TORONTO, ONTARIO, CANADA (1)
4,661,235 Chemo-receptive lipid based membrane transducers 70 1984
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
H201 Biosensors from membrane proteins reconstituted in polymerized lipid bilayers 27 1985

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
OSMETECH TECHNOLOGY INC. (30)
6,096,273 Electrodes linked via conductive oligomers to nucleic acids 69 1996
7,381,525 AC/DC voltage apparatus for detection of nucleic acids 5 1997
7,014,992 Conductive oligomers attached to electrodes and nucleoside analogs 15 1997
6,221,583 Methods of detecting nucleic acids using electrodes 59 1997
6,232,062 AC methods for the detection of nucleic acids 48 1997
7,560,237 Electronics method for the detection of analytes 4 1998
6,290,839 Systems for electrophoretic transport and detection of analytes 48 1998
6,600,026 Electronic methods for the detection of analytes utilizing monolayers 17 1999
6,264,825 Binding acceleration techniques for the detection of analytes 199 1999
6,740,518 Signal detection techniques for the detection of analytes 58 1999
7,160,678 Compositions for the electronic detection of analytes utilizing monolayers 108 1999
6,833,267 Tissue collection devices containing biosensors 2 1999
6,824,669 Protein and peptide sensors using electrical detection methods 8 2000
7,045,285 Electronic transfer moieties attached to peptide nucleic acids 14 2000
6,479,240 Electrodes linked via conductive oligomers to nucleic acids 34 2000
6,686,150 Amplification of nucleic acids with electronic detection 26 2000
7,935,481 Sequence determination of nucleic acids using electronic detection 0 2000
6,495,323 AC methods for the detection of nucleic acids 26 2000
7,087,148 Binding acceleration techniques for the detection of analytes 19 2000
7,312,087 Devices and methods for biochip multiplexing 8 2001
7,172,897 Devices and methods for biochip multiplexing 24 2001
6,977,151 Electrodes linked via conductive oligomers to nucleic acids 15 2002
7,056,669 AC methods for the detection of nucleic acids 13 2002
7,655,129 Binding acceleration techniques for the detection of analytes 0 2004
7,393,645 Compositions for the electronic detection of analytes utilizing monolayers 0 2005
7,381,533 Electrodes linked via oligomers to nucleic acids 0 2005
7,713,711 Electronic methods for the detection of analytes 0 2007
7,601,507 Electronic methods for the detection of analytes 1 2007
7,759,073 Electronic methods for the detection of analytes 0 2009
8,114,661 Electronic methods for the detection of analytes 0 2010
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (13)
6,001,556 Polymeric assay film for direct colorimetric detection 30 1996
6,183,772 Doped colorimetric assay liposomes 9 1996
6,017,390 Growth of oriented crystals at polymerized membranes 39 1997
6,103,217 Polymeric assemblies for sensitive colorimetric assays 12 1997
6,022,748 Sol-gel matrices for direct colorimetric detection of analytes 86 1997
6,180,135 Three-dimensional colorimetric assay assemblies 5 1997
6,468,759 Direct colorimetric detection of biocatalysts 12 1998
6,395,561 Polymeric assay film for direct colorimetric detection 6 1999
6,485,987 Sol-gel matrices for direct colorimetric detection of analytes 6 2000
6,660,484 Colorimetric glycopolythiophene biosensors 15 2000
7,049,152 Color and shape changing polymeric ribbons and sheets 1 2002
7,051,569 Systems and methods for calibrating osmolarity measuring devices 1 2004
7,204,122 Systems and methods for calibrating osmolarity measuring devices 1 2006
 
3M INNOVATIVE PROPERTIES COMPANY (6)
6,963,007 Diacetylenic materials for sensing applications 7 2002
7,364,918 Colorimetric sensors constructed of diacetylene materials 0 2003
7,816,472 Polydiacetylene polymer compositions and methods of manufacture 0 2004
7,371,511 Polydiacetylene polymer blends 1 2004
7,816,473 Diacetylenic materials for sensing applications 1 2005
8,063,164 Diacetylenic materials for sensing applications 0 2010
 
KEENSENSE, INC. (5)
6,060,327 Molecular wire injection sensors 185 1997
6,326,215 Molecular wire injection sensors 29 1999
6,699,667 Molecular wire injection sensors 11 2001
6,979,544 Molecular wire injection sensors 81 2004
7,220,550 Molecular wire injection sensors 1 2005
 
PLEXERA, LLC (5)
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8,004,669 SPR apparatus with a high performance fluid delivery system 2 2008
8,107,082 SPR apparatus with a high performance fluid delivery system 1 2011
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PENCE, INC. (4)
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5,955,379 Biosensor device and method 14 1997
6,478,939 Biosensor device and method 10 2000
6,461,490 Biosensor device and method 10 2000
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (3)
6,291,188 Metallic solid supports modified with nucleic acids 17 2000
6,528,266 Nucleic acid mediated electron transfer 18 2001
7,033,760 Metallic solid supports modified with nucleic acids 1 2001
 
P.J. EDMONSON LTD. (2)
7,451,649 Differentiation and identification of analogous chemical or biological substances with biosensors 2 2005
7,650,788 Differentiation and identification of analogous chemical or biological substances with biosensors 2 2007
 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (2)
6,306,584 Electronic-property probing of biological molecules at surfaces 34 1997
6,809,196 Molecular recognition at surfaces derivatized with self-assembled monolayers 19 2001
 
RELIANCE ELECTRIC TECHNOLOGIES, LLC (2)
6,218,749 Electric motor having rotor-embedded sensor 10 1998
6,504,275 Electric motor having rotor-embedded sensor 15 2001
 
AGILENT TECHNOLOGIES, INC. (1)
6,319,674 Methods for attaching substances to surfaces 34 1999
 
ALCATEL-LUCENT USA INC. (1)
7,534,646 Method of fabricating an organic field transistor 0 2006
 
ALPHA MOS (1)
7,115,229 Apparatus and method for monitoring molecular species within a medium 4 2001
 
CLINICAL MICRO SYSTEMS, INC. (1)
6,761,816 Printed circuit boards with monolayers and capture ligands 24 2000
 
CLINICAL MIRCO SENSORS, INC. (1)
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HELIX BIOPHARMA CORPORATION (1)
6,787,368 Biosensor method for detecting analytes in a liquid 45 2000
 
LUCENT TECHNOLOGIES INC. (1)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
7,291,503 Reversible resistivity-based sensors 4 2003
 
MATUSHITA SEIKO CO., LTD. (1)
7,662,612 Chemical sensor device 0 2001
 
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (1)
6,570,196 Lipid vesicles or lipid bilayers on chips 7 2000
 
MCGILL UNIVERSITY (1)
6,107,080 Biosensor device and method 31 1997
 
MOTOROLA SOLUTIONS, INC. (1)
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OSMETCH TECHNOLOGY, INC. (1)
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ROHM CO., LTD. (1)
7,939,884 Semiconductor device 0 2006
 
TEARLAB RESEARCH, INC. (1)
8,020,433 Systems and methods for a sample fluid collection device 0 2008