Monoclonal antibodies which bind both transforming growth factors .beta.1 and .beta.2 and methods of use
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United States of America Patent
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Nov 5, 1996
Issued Date -
N/A
app pub date -
Sep 6, 1991
filing date -
Dec 22, 1988
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Abstract
Monoclonal antibodies have been produced which bind to Transforming Growth Factors .beta.1 (TGF-.beta.1) and .beta.2 (TGF-.beta.2). The monoclonal antibody produced by the hybridoma designated 1D11.16 deposited as A.T.C.C. Accession No. HB 9849 binds to both TGF-.beta.1 and TGF-.beta.2. The antibodies are produced by immunizing with TGF-.beta.2 and may be of any isotype. The antibodies may be of any mammalian origin such as murine or human origin. Diagnostic and therapeutic applications utilizing the monoclonal antibodies are also disclosed.
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