Method of inducing gene expression by ionizing radiation
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United States of America Patent
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Nov 5, 1996
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N/A
app pub date -
May 11, 1994
filing date -
May 11, 1994
priority date (Note) -
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Abstract
The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. The radiation source may be will generally be in the form of a radionuclide, capable of gamma or beta emissions. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
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