Hydrophilic microporous membrane for drug delivery devices and method for preparing same
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United States of America Patent
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-
Nov 12, 1996
Issued Date -
N/A
app pub date -
Jun 1, 1995
filing date -
Oct 30, 1990
priority date (Note) -
Expired
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Abstract
Articles having a complex geometric configuration have hydrophilicity imparted to at least a portion of surfaces of the articles while substantially retaining the complex geometric configuration. The hydrophilicity is imparted by an extremely thin, self-interlocking shell of tactic, hydrophilic poly(vinyl alcohol) enveloping the surfaces. A tactic poly(vinyl alcohol) precursor applied to surfaces of the supporting structure is reacted in situ on the surfaces with a hydrolysis reagent to prepare the tactic, hydrophilic poly(vinyl alcohol) shell. The article having the hydrophilic shell is highly resistant to solvent washout. Hydrophilicity and hydrophobicity can be reversibly provided on regio-specific surfaces of the article. Articles in the form of membranes useful as drug delivery device components are also described.
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