Selective inhibitors of biogenic amine transporters

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United States of America Patent

PATENT NO 5574060
SERIAL NO

08203222

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH.sub.3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, OCH.sub.3, OH, CF.sub.3, OCF.sub.3, NO.sub.2, NH.sub.2, N(CH.sub.3).sub.2, NHCOCH.sub.3, NCS, NHCOCH.sub.2 Br, or N.sub.3, and (CH.sub.2).sub.n, if present, may be substituted with OH, OCH.sub.3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.

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Patent Owner(s)

Patent OwnerAddress
RESEARCH TRIANGLE INSTITUTE3040 EAST CORNWALLIS RESEARCH TRIANGLE PARK NC 27709
UNITED STATES OF AMERICA THE AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESC/O NATIONAL INSTITUTES OF HEALTH OFFICE OF TECHNOLOGY TRANSFER BOX OTT BETHESDA MD 20892

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blough, Bruce Raleigh, NC 3 2
Carroll, Frank J Durham, NC 1 1
Mascarella, Samuel W Hillsborough, NC 2 2
Rothman, Richard Silver Spring, MD 6 5

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