Palatable pharmaceutical compositions
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United States of America Patent
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Nov 26, 1996
Issued Date -
N/A
app pub date -
Feb 15, 1995
filing date -
Jun 4, 1992
priority date (Note) -
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status (Latency Note)
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Abstract
A pharmaceutical granular composition and method are provided for masking the taste of unpleasant tasting drugs, wherein drug cores are coated with separate layers of aqueous dispersions of methacrylate ester copolymers, preferably, poly(ethylacrylate, methyl methacrylate) to which quaternary ammonium groups have been introduced to modify the permeability of the ester. Additionally, the coating composition may contain plasticizers and conventional excipients. The coating system releases drug by diffusion and is influenced by drug solubility and media pH. The coated pharmaceutical granules of the invention can be used to prepare chewable tablets with good palatability and bioavailability.
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