Method for determining endotoxin and apparatus therefor

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5578455
SERIAL NO

08209247

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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There is disclosed a method for determining an endotoxin by reacting the endotoxin adsorbed on an adsorbent having specific endotoxin adsorbability with an endotoxin detecting reagent, including the steps of: (a) preparing a column having a tip opening, a rear end opening and an adsorbent-filling and holding means provided in the column through which a sample solution can pass, (b) introducing the endotoxin adsorbent into the column through the tip opening to fill and hold the adsorbent therein, (c) introducing the sample solution into the column through the tip opening and discharging the introduced sample solution through the rear end opening to contact the sample and the adsorbent and thereby adsorbing the endotoxin on the adsorbent, and (d) reacting the detecting reagent with the endotoxin adsorbed on the adsorbent. There is also disclosed an apparatus for the above method.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
TANABE SEIYAKU CO., LTD.OSAKA46

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Masuda, Makoto Takarazuka, JP 31 159
Minobe, Satoshi Otsu, JP 6 92
Shibatani, Takeji Kobe, JP 15 43
Tosa, Tetsuya Kyoto, JP 9 71
Watanabe, Taizo Nagaokakyo, JP 5 88

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ABBOTT LABORATORIES (1)
* 4276050 Method for systemic endotoxin detection 16 1980
 
MANAC INC. (1)
* 5186839 Syringe type column for chromatography 13 1991
 
TANABE SEIYAKU CO., LTD. (1)
* 5342785 Method for determining pyrogen content 2 1993
 
AGILENT TECHNOLOGIES, INC. (1)
* 5336412 Push column chromatography method 17 1993
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Prometic Biosciences Ltd. (2)
* 6773599 Triazine-based detoxification agents and their use 6 2002
7364656 Triazine-based detoxification agents and their use 0 2006
 
NIPRO CORPORATION (1)
* 2004/0235,195 Methods for measuring and diagnosing endotoxin, sensor therefor, and method for producing and reusing the sensor 1 2004
 
AGQ TECHNOLOGICAL CORPORATE S.A. (2)
* 6852286 Device for extracting and taking samples from an aqueous solution in a substrate 1 2001
* 2001/0051,111 Device for extracting and taking samples from an aqueous solution in a substrate 0 2001
 
JNC CORPORATION (2)
* 6699386 Endotoxin adsorbent, and a method of removing endotoxin by using the same 3 2002
* 2002/0130,082 Endotoxin adsorbent, and a method of removing endotoxin by using the same 5 2002
 
VENTURE LENDING & LEASING IV, INC. (1)
* 2005/0014,678 Novel triazine-based detoxification agents and their use 1 2004
 
LIFENET HEALTH (1)
9339589 Method of demineralizing bone 0 2012
 
TECAN TRADING AG (1)
* 5709840 Reactor flask 14 1996
 
LIFENET HEATH (2)
* 8337780 Apparatus for demineralizing osteoinductive bone 3 2010
* 2011/0027,871 Apparatus for Demineralizing Osteoinductive Bone 0 2010
 
VENTANA MEDICAL SYSTEMS, INC. (9)
* 6537818 System and method of aspirating and dispensing reagent 34 2001
7270785 Automated molecular pathology apparatus having fixed slide platforms 34 2002
7303725 Automated high volume slide staining system 55 2003
7378055 Automated molecular pathology apparatus having fixed slide platforms 50 2003
7468161 Automated high volume slide processing system 35 2005
8663991 Automated high volume slide processing system 1 2005
7404927 Automated molecular pathology apparatus having fixed slide platforms 31 2005
8048373 Automated high volume slide staining system 4 2007
9528918 Automated high volume slide processing system 0 2013
* Cited By Examiner