Method for the preparation of S-(+)-ethodolic acid and saline derivatives
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United States of America Patent
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Nov 26, 1996
Grant Date -
N/A
app pub date -
Jun 29, 1994
filing date -
Jan 14, 1993
priority date (Note) -
Expired
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Abstract
Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of a mixture of alpha-(+)-phenethylamine enantiomers in an organic solvent. The resulting precipitate containing the salt of optically active phenethylamine and the S-(+)-enantiomer of the ethodolic acid is separated followed by isolation of the optically enantiomer. Salification of the acid with organic and inorganic bases, selected from basis amino acids, morpholine, aminopyridine and benzylalkyltrimethylammonium derivatives provides new therapeutically effective derivatives.
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