US Patent No: 5,580,756

Number of patents in Portfolio can not be more than 2000

B7IG fusion protein

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Abstract

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The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C.gamma.1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BRISTOL-MYERS SQUIBB COMPANYPRINCETON, NJ1843

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brady, William Bothell, WA 47 1060
Damle, Nitin K Monmount Junction, NJ 34 974
Ledbetter, Jeffrey A Shoreline, WA 136 2951
Linsley, Peter S Seattle, WA 100 2078

Cited Art Landscape

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Patent Citation Ranking

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Other [Check patent profile for assignment information] (1)
8,435,952 Method for retarding progression to definite rheumatoid arthritis in subjects with undifferentiated arthritis 2 2011
 
BRISTOL-MYERS SQUIBB COMPANY (20)
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