B7IG fusion protein

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5580756
SERIAL NO

08219518

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C.gamma.1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BRISTOL-MYERS SQUIBB COMPANYPRINCETON, NJ1936

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brady, William Bothell, WA 43 1262
Damle, Nitin K Renton, WA 32 1120
Ledbetter, Jeffrey A Seattle, WA 120 3804
Linsley, Peter S Seattle, WA 83 2549

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