Pt-containing compound, process for its preparation, and application of such compounds
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United States of America Patent
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Dec 3, 1996
Grant Date -
N/A
app pub date -
Oct 29, 1993
filing date -
Jul 19, 1990
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Abstract
Pt-containing compound with the formula {Pt.sup.II (w)(x)(y)(z)} or {Pt.sup.IV (u)(v)(w)(x)(y)(z)}, wherein u, v, w, x, y and z represent whether or not the same whether or not interconnected ligands, of which at least one is a leaving ligand and at least one of the remaining ligands represents a detectable marker group. According to the invention (CH.sub.3).sub.2 SO, Cl or H.sub.2 O appears to be suitable as a leaving ligand while as detectable marker group a fluorescent group merits preference and is the ligand fluorescein or tetramethyl rhodamine. A suitable Pt-containing compounds is {Pt(ethylenediamine)(Me.sub.2 SO)(fluorescein-NH(CS)-NHCH.sub.3)} (PtF). Further, the invention comprises a process for the preparation of the Pt-containing compounds, where the Pt-containing compounds are prepared in a manner known per se for analogous compounds.
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