T-cadherin adhesion molecule
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United States of America Patent
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Dec 17, 1996
Issued Date -
N/A
app pub date -
Mar 14, 1994
filing date -
Oct 30, 1990
priority date (Note) -
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Abstract
The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadherin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of detecting tumor growth which consists of inhibiting the activity of T-cadherin in a tumor. A method of effecting traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.
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