Reduction of elevated blood lactate using twice-daily dichloroacetate
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United States of America Patent
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Dec 24, 1996
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N/A
app pub date -
Jun 8, 1995
filing date -
Jun 8, 1995
priority date (Note) -
Expired
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Abstract
This invention discloses an improved method of reducing elevated lactic acid and lactate concentrations in patients suffering from ischemic or hypoxic crises as stroke, cardiac arrest, or heart attacks, or other conditions involving surgery, that generate unwanted increases in blood or tissue lactate concentrations. This improvement comprises administering dichloroacetate (DCA), as in the sodium salt form, less than three times daily, at suitable dosages which cause the beneficial effects of DCA to persist beyond the time when the DCA has been pharmacokinetically cleared from the blood circulating in the patient.
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