Hybridization promotion reagents
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United States of America Patent
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Dec 31, 1996
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N/A
app pub date -
Aug 11, 1994
filing date -
Apr 5, 1989
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Abstract
Novel reagents are provided along with methods for their use in nucleic acid hybridization assays for detecting target nucleic acids in samples. The most preferred reagent is a mixture of guanidinium thiocyanate and tetramethylammonium:Trifluoracetate and possesses many properties for facilitating hybridization between target nucleic acid and nucleic acid probes capable of binding thereto and surprisingly results in the phenomenon of superstoichiometric labeling.
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