Dissolution testing apparatus

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5589649
SERIAL NO

08389063

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The dissolution testing apparatus has a plurality of stirring elements for stirring the test solutions within a plurality of test vessels with reflective surfaces. The temperatures of the test solutions are individually controlled by a temperature control system. The temperature control system includes a controller, a heating element for each test vessel to heat the corresponding test solution, and a temperature sensor for each test vessel to measure the temperature of the corresponding test solution. The heating elements are wrapped around the outside of the test vessels and held in place by spring-loaded heater jackets. Each stirring element has a hollow shaft, a detachable stirring attachment (e.g., blade or basket), a temperature sensor inside the hollow shaft, and a signal transfer device to transmit signals from the temperature sensor to the controller. The test vessels are supported and aligned with respect to the stirring elements with a holding plate having openings and corresponding alignment fixtures.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
Distek, Inc.NORTH BRUNSWICK, NJ11

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brinker, Gerald North Brunswick, NJ 4 63
Gutwillig, Alan Sterling, VA 7 253
Hladik, Peter Piscataway, NJ 2 57

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (4)
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* 4279860 Multiple injector flow through dissolution cell for dissolution testing apparatus 33 1980
* 5011662 Dissolution testing machine 14 1987
* 5280678 Method and apparatus for monitoring the processing of a material 6 1992
 
ERWEKA GMBH (2)
* 4754657 Disintegration testing device 22 1986
* 4924716 Dissolution testing apparatus 28 1989
 
Beckman Instruments, Inc. (1)
* 4858155 Reaction temperature control system 55 1985
 
SNAP-TITE TECHNOLOGIES, INC. (1)
* 4466276 Consistometer 25 1982
 
B&P PROCESS EQUIPMENT AND SYSTEMS L.L.C. (1)
* 4704035 Remotely transmitting batch mixer 32 1986
 
Burroughs Wellcome Co. (1)
* 4464340 Dissolution flask 7 1981
 
WARNER-LAMBERT COMPANY LLC (1)
* 4681858 Dissolution cell and method for determining the in-vitro release of a drug 15 1986
 
PHARMA TEST APPARATEBAU GMBH (1)
* 4879917 Apparatus for determining the active ingredient release from soluble pharmaceutical products 24 1988
 
RORER PHARMACEUTICAL CORPORATION (1)
* 4856909 Pharmacological dissolution method and apparatus 19 1986
 
VENTANA MEDICAL SYSTEMS, INC. (1)
* 5023187 Method and device for accelerated treatment of thin sample on surface 90 1988
 
NALGE COMPANY (1)
* 5080232 Test tube rack and retainer 51 1991
 
UNITED TECHNOLOGIES CORPORATION (1)
* 4715723 Arrangement for controllably mixing volatile materials 5 1986
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (3)
6336739 Air bath dissolution tester 6 2001
7237436 Dosage form holder device and methods for immersion testing 2 2006
* 2006/0207,356 Dosage form holder device and methods for immersion testing 0 2006
 
TELEDYNE INSTRUMENTS, INC. (1)
D688963 Sampling machine 0 2012
 
RIGGTEK GMBH (2)
8899101 Apparatus for sample handling 0 2011
* 2011/0197,661 APPARATUS FOR SAMPLE HANDLING 2 2011
 
AVENTISUB LLC (1)
* 6929782 Dissolution test sample holder 6 2000
 
Andrx Labs, LLC (1)
7051606 Dosage form holder device and methods for immersion testing 2 2004
 
Biokit, S.A. (1)
D565741 Mixing tube 6 2007
 
DAKO DENMARK A/S (6)
7718435 Automated slide stainer with slide housing 11 2000
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SONABANK (1)
* 6296764 Apparatus for mixing and separating particulate matter from a fluid 27 1998
 
Distek, Inc. (7)
* 5983515 Apparatus for measuring heights in dissolution testing equipment 7 1997
6497157 Intrinsic dissolution apparatus with stationary sample holder 8 2000
* 6948389 Dissolution test sampling 6 2003
* 2003/0217,608 Dissolution test sampling 2 2003
9333469 Multi-motion assembly for leadscrew system 0 2011
8903673 Centrally controlled modular motorized testing 0 2012
* 2012/0232,824 CENTRALLY CONTROLLED MODULAR MOTORIZED TESTING 0 2012
 
VENTANA MEDICAL SYSTEMS, INC. (6)
7425306 Slide heater 12 2001
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7378055 Automated molecular pathology apparatus having fixed slide platforms 50 2003
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7615371 Method and apparatus for treating a biological sample with a liquid reagent 9 2004
7404927 Automated molecular pathology apparatus having fixed slide platforms 31 2005
 
UNIFLEX COMPANY, LTD. (1)
* 2011/0048,145 DISSOLUTION TESTING APPARATUS FOR PHARMACEUTICAL PREPARATIONS 0 2010
 
KINETANA GROUP INC. (1)
* 6022733 Simulated biological dissolution and absorption system 18 1997
 
DELPHIAN TECHNOLOGY, INC. (2)
6174497 Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form 21 1997
6558957 Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form 61 2000
 
VARIAN, INC. (1)
* 2009/0208,373 Captive evaporation cover for dissolution systems 1 2008
 
VANKEL TECHNOLOGY GROUP (2)
6434847 Methods and apparatus for determining the location of a shaft within a vessel 2 1999
6303909 Waterless vessel heating system and method 11 2000
 
ROHM AND HAAS COMPANY (2)
* 8584539 Delivery device for dispensing pharmaceutical dosage forms into dissolution testing apparatus 0 2011
* 2012/0000,275 DELIVERY DEVICE FOR DISPENSING PHARMACEUTICAL DOSAGE FORMS INTO DISSOLUTION TESTING APPARATUS 0 2011
 
ALKERMES PHARMA IRELAND LIMITED (2)
* 7021163 Apparatus and method for concurrently monitoring active release and physical appearance of solid dosage form pharmaceuticals 4 2002
* 2005/0003,550 Apparatus and method for concurrently monitoring active release and physical appearance of solid dosage form pharmaceuticals 2 2002
 
AGILENT TECHNOLOGIES, INC. (14)
6562301 Vessel centering system and method 6 2000
6673319 Vessel centering system and method 6 2001
6474182 Methods and apparatus for determining the location of a shaft within a vessel 1 2001
6727480 Waterless vessel heating system and method 7 2001
* 7914741 Automated microsampling dissolution test system 1 2008
* 2008/0226,499 Automated microsampling dissolution test system 2 2008
* 2009/0208,377 Dissolution test vessel with integrated centering geometry 3 2008
* 2009/0207,691 Dissolution test vessel with rotational agitation 3 2008
* 7938032 Dissolution testing with in-situ gravimetric volume measurement 2 2008
* 2010/0107,752 DISSOLUTION TESTING WITH IN-SITU GRAVIMETRIC VOLUME MEASUREMENT 1 2008
8430257 Dissolution test vessel with integral verticality control 2 2009
* 2011/0079,096 DISSOLUTION TEST VESSEL WITH INTEGRAL VERTICALITY CONTROL 1 2009
8511148 Dissolution test vessel with integral centering 1 2009
* 2011/0120,239 DISSOLUTION TEST VESSEL WITH INTEGRAL CENTERING 1 2009
 
NEW JERSEY INSTITUTE OF TECHNOLOGY (1)
* 2012/0042,737 NOVEL DISSOLUTION TESTING SYSTEM AND APPARATUS WITH OFF-CENTER IMPELLER 0 2011
 
I.C.T.C. HOLDINGS CORPORATION (2)
* 6652135 Stirring apparatus for large containers 3 2001
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MERCK PATENT GMBH (2)
* 8617491 Device for receiving a solid in a measuring cell 0 2009
* 2011/0113,867 DEVICE FOR RECEIVING A SOLID IN A MEASURING CELL 0 2009
 
BASF AKTIENGESELLSCHAFT (1)
* 6149295 Measurement of parameters in reactors having moving stirrers 5 1999
 
BECKMAN COULTER BIOMEDICAL, LLC. (2)
* 9568428 Diagnostic instrument and flow process 0 2011
* 2013/0143,309 DIAGNOSTIC INSTRUMENT AND FLOW PROCESS 0 2011
* Cited By Examiner