Transduced mesenchymal stem cells

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United States of America Patent

PATENT NO 5591625
SERIAL NO

08158000

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Genetically engineered human stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins or for use in gene therapy. In addition to correction of genetic disorders, is the ability to introduce, in a targeted manner, additional copies of essential genes to allow expression in proliferating, nondifferentiating cells of certain gene products. These genes can be, for example, hormones matrix proteins, cytokines, adhesion molecules, detoxification enzymes and 'rebuilding' proteins important in tissue repair.

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Patent Owner(s)

  • CASE WESTERN RESERVE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Caplan, Arnold I Cleveland Heights, OH 26 4800
Gerson, Stanton L Pepper Pike, OH 11 520
Haynesworth, Stephen E Cleveland Heights, OH 12 3487

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