US Patent No: 5,595,723

Number of patents in Portfolio can not be more than 2000

Method for preparing storage stable colloids

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Abstract

Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to an organism. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
GE HEALTHCARE ASOSLO264

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Quay, Steven C Edmonds, WA 171 1855

Cited Art

Patent Info (Count) # Cites Year
 
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SCHERING AKTIENGESELLSCHAFT (7)
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LANTHEUS MEDICAL IMAGING, INC. (4)
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MOLECULAR BIOSYSTEMS, INC. (4)
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SLF LIMITED PARTNERSHIP (3)
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UNIVERSITY OF MASSACHUSETTS (2)
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GE HEALTHCARE AS (1)
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HEMAGEN/PFC, 655 MONTGOMERY STREET, SUITE 1710, SAN FRANCISCO, CA. 94111, A LIMITED PARTNERSHIP OF CA. (1)
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I.S.C. CHEMICALS LIMITED (1)
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KABUSHIKI KAISHA TOSHIBA (1)
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KALI-CHEMIE AG (1)
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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
LANTHEUS MEDICAL IMAGING, INC. (24)
5,769,080 Gas filled liposomes and stabilized gas bubbles and their use as ultrasonic contrast agents 19 1994
5,830,430 Cationic lipids and the use thereof 82 1995
5,853,752 Methods of preparing gas and gaseous precursor-filled microspheres 79 1995
5,776,429 Method of preparing gas-filled microspheres using a lyophilized lipids 28 1996
6,001,335 Contrasting agents for ultrasonic imaging and methods for preparing the same 7 1996
6,146,657 Gas-filled lipid spheres for use in diagnostic and therapeutic applications 38 1996
6,039,557 Apparatus for making gas-filled vesicles of optimal size 20 1997
6,528,039 Low density microspheres and their use as contrast agents for computed tomography and in other applications 16 1997
5,985,246 Contrast agents for ultrasonic imaging and methods for preparing the same 2 1997
6,548,047 Thermal preactivation of gaseous precursor filled compositions 36 1997
6,071,495 Targeted gas and gaseous precursor-filled liposomes 76 1997
6,231,834 Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same 76 1997
6,033,646 Method of preparing fluorinated gas microspheres 7 1998
6,551,576 Container with multi-phase composition for use in diagnostic and therapeutic applications 26 1998
6,056,938 Cationic lipids and the use thereof 43 1998
6,479,034 Method of preparing gas and gaseous precursor-filled microspheres 12 1998
6,071,494 Methods for diagnostic imaging using a contrast agent and a renal vasodilator 18 1998
6,254,852 Porous inorganic targeted ultrasound contrast agents 8 1999
6,884,407 Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator 8 2000
6,773,696 Contrast agent comprising low density microspheres 9 2002
7,052,673 Pharmaceuticals for the imaging of angiogenic disorders 3 2003
8,084,056 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2003
6,998,107 Composition comprising low density microspheres 2 2004
7,344,705 Composition comprising low density microspheres 1 2005
 
CEREVAST THERAPEUTICS, INC. (15)
5,922,304 Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents 52 1995
6,088,613 Method of magnetic resonance focused surgical and therapeutic ultrasound 43 1995
5,770,222 Therapeutic drug delivery systems 171 1995
6,743,779 Methods for delivering compounds into a cell 15 1997
6,537,246 Oxygen delivery agents and uses for the same 27 1997
6,123,923 Optoacoustic contrast agents and methods for their use 44 1997
6,315,981 Gas filled microspheres as magnetic resonance imaging contrast agents 40 1999
6,444,660 Lipid soluble steroid prodrugs 9 2000
6,403,056 Method for delivering bioactive agents using cochleates 14 2000
7,452,551 Targeted compositions for diagnostic and therapeutic use 1 2000
6,638,767 Methods for delivering compounds into a cell 10 2000
6,716,412 Methods of ultrasound treatment using gas or gaseous precursor-filled compositions 21 2001
6,576,220 Non-invasive methods for surgery in the vasculature 11 2001
6,808,720 Charged lipids and uses for the same 6 2002
7,105,151 Oxygen delivery agents and uses for the same 3 2003
 
IMARX THERAPEUTICS, INC. (12)
5,733,572 Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles 146 1994
5,874,062 Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents 34 1995
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5,997,898 Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery 22 1995
6,443,898 Therapeutic delivery systems 34 1995
6,414,139 Silicon amphiphilic compounds and the use thereof 15 1996
6,143,276 Methods for delivering bioactive agents to regions of elevated temperatures 46 1997
6,090,800 Lipid soluble steroid prodrugs 18 1997
6,120,751 Charged lipids and uses for the same 71 1997
6,139,819 Targeted contrast agents for diagnostic and therapeutic use 51 1997
6,117,414 Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents 6 1997
7,078,015 Ultrasound imaging and treatment 19 2004
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (5)
5,814,601 Methods and compositions for optimization of oxygen transport by cell-free systems 18 1997
6,054,427 Methods and compositions for optimization of oxygen transport by cell-free systems 24 1998
6,444,192 Diagnostic imaging of lymph structures 15 1999
6,432,918 Methods and compositions for optimization of oxygen transport by cell-free systems 23 2000
7,101,846 Methods and compositions for optimization of oxygen transport by cell-free systems 7 2004
 
SANGART, INC. (3)
6,844,317 Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin 15 2003
7,625,862 Method for making a high oxygen affinity modified hemoglobin for oxygen transport 7 2007
7,989,414 Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin 1 2009
 
THE PROCTER & GAMBLE COMPANY (3)
7,851,668 Absorbent article and method for maintaining or improving skin health 0 2006
8,138,388 Absorbent article and method for maintaining or improving skin health 0 2010
8,420,883 Absorbent article and method for maintaining or improving skin health 0 2011
 
BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. (2)
6,416,740 Acoustically active drug delivery systems 75 1998
7,083,572 Therapeutic delivery systems 6 2002
 
IMARX PHARMACEUTICAL CORP. (2)
7,329,402 Methods of imaging and treatment 18 2003
7,612,033 Methods for delivering compounds into a cell 0 2004
 
TARGESON, INC. (2)
6,802,813 Methods and apparatus for monitoring and quantifying the movement of fluid 6 2003
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AMERSHAM HEALTH AS (1)
5,897,851 Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging 27 1996
 
DUPONT PHARMACEUTICALS COMPANY (1)
6,521,211 Methods of imaging and treatment with targeted compositions 56 1999
 
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (1)
8,183,314 Emulsion compositions with a polymeric emulsifier 0 2009
 
IMARX PHARMACEUTICAL (1)
6,461,586 Method of magnetic resonance focused surgical and therapeutic ultrasound 15 2000
 
MWO GESELLSCHAFT ZUR HERSTELLUNG VON CHEMISCH-TECHNISCHEN PRODUKTEN MBH (1)
6,188,828 Filling material 1 1999
 
REVIVO, JACOB (1)
7,101,578 Salt sorbet facial and body scrub 2 2004
 
RHODIA OPERATIONS (1)
7,404,442 Method of recycling fracturing fluids using a self-degrading foaming composition 0 2006
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
6,776,995 Souffle facial and body scrub 0 2002