Liposomal compositions for enhanced retention of bioactive agents
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United States of America Patent
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Jan 21, 1997
Grant Date -
N/A
app pub date -
Dec 22, 1993
filing date -
Dec 22, 1993
priority date (Note) -
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Abstract
Liposomal compositions encapsulating bioactive agents and having improved circulation longevity of the agents are disclosed. Such liposomes combine a low pH of the solution in which a bioactive agent is entrapped and a sugar-modified lipid or an amine-bearing lipid, the combination of which enhances the retention of the encapsulated bioactive agent and thereby promotes circulation longevity. The present invention also discloses methods of making and using such compositions.
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