Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jan 21, 1997
Grant Date -
N/A
app pub date -
Mar 18, 1994
filing date -
Mar 18, 1994
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Replacement of the natural nucleotides with unnatural zwitterionic nucleotides having a cationic moiety tethered to the base (or analog thereof) results in oligodeoxynucleotides with diminished charge but undiminished ability to complex with DNA at low ionic strengths. We have now discovered that DNA can be made fully zwitterionic by introducing tethered cationic moieties to the bases without affecting duplex formation. The resulting oligonucleotides have the further advantages of being nuclease resistant.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully