Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5597733
SERIAL NO

08404168

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An analyzer for chemical assays includes a turntable which supports sample containers and reagent containers within a cooled volume and test cells about the periphery of the cooled volume. A probe is carried by a rotating arm for withdrawing liquid from the containers and dispensing the liquid. Fixed stations are also provided in the path of the probe. One such station serves to both wash the tip of the probe and to receive samples for flow-through analysis. Heaters associated with the probe and with the test cells increase the rate of reaction. Curved walls of test cell segments match the optics of an optical analyzer so that light from the analyzer lamp is generally orthogonal to the curved surfaces. The light voltage of the lamp may be controlled as a function of lamp wavelength required for particular assays. The system provides multiple-point calibration and automatic dilution of samples. Multiple aliquots of reagent may be drawn into the probe and then be dispensed into separate test cells. Individual aliquots of sample may be drawn and dispensed with the reagent.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
Precision Systems, Inc.NATICK, MA3

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bell, Charles A Weston, MA 8 246
Heath, Warren J Marlboro, MA 7 237
Kleinman, Norman M Framingham, MA 2 105

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Rainin Instrument, LLC (1)
* 4905526 Portable automated pipette for accurately pipetting and/or titrating liquids 41 1987
 
Coulter Electronics, Inc. (2)
* 4276051 System and program for chemical reaction observation with a moving photometer 126 1980
* 4326851 Level sensor apparatus and method 71 1980
 
Beckman Instruments, Inc. (1)
* 4888998 Sample handling system 36 1989
 
ABBOTT LABORATORIES (1)
* 4933147 Unitized reagent containment system for clinical analyzer 85 1987
 
SERONO DIAGNOSTICS, INC. A CORP. OF DELAWARE (1)
* 4344768 Automatic pipettor 80 1981
 
OLYMPUS OPTICAL CO., LTD. (2)
* 4311667 Delivering apparatus 64 1980
* 4456037 Process of delivering samples and reagents 46 1982
 
Japan Spectroscopic Co., Ltd. (1)
* 4429583 Liquid uptake and discharge apparatus 26 1982
 
HITACHI, LTD. (1)
* 5051238 Automatic analyzing system 171 1988
 
Technicon Instruments Corporation (1)
* 4357301 Reaction cuvette 35 1981
 
Hanuman LLC (1)
* 2004/0182,788 Plasma concentrate apparatus and method 24 2003
 
TOA MEDICAL ELECTRONICS CO., LTD. (1)
* 5215714 Immunoagglutination measurement apparatus 88 1991
 
KABUSHIKI KAISHA TOSHIBA (2)
* 4675162 Automatic chemical analyzing apparatus 7 1985
* 4906433 Automatic chemical analyzer 113 1989
 
JAPAN TECTRON INSTRUMENTS CORPORATION (1)
* 4774055 Automatic analysis apparatus 195 1986
 
ROCHE DIAGNOSTICS CORPORATION (1)
* 4639135 Cuvette 29 1985
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2006/0093,520 Automated molecular pathology apparatus having fixed slide platforms 1 2005
 
BECEEM COMMUNICATIONS, INC. (3)
6793888 Method and system for sample aliquot storage 4 2001
* 2006/0205,082 Reaction rate determination 0 2005
RE46214 Method and system for sample aliquot storage 0 2006
 
BOVAL COMPANY, LP (1)
6793387 Apparatus for automatic preparation of a mixture and method 48 2002
 
Drummond Scientific Company (2)
7396512 Automatic precision non-contact open-loop fluid dispensing 11 2003
* 2005/0095,723 Automatic precision non-contact open-loop fluid dispensing 4 2003
 
ABBOTT LABORATORIES (1)
* 6063634 Fluid assembly and method for diagnostic instrument 5 1998
 
FREESLATE, INC. (8)
6866786 Rapid characterization of polymers 6 2002
6855258 Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling 18 2002
6730228 Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling 21 2002
7549978 Needle assembly 33 2005
* 2005/0211,622 Apparatuses and methods for creating and testing pre-formulations and systems for same 1 2005
7507337 System and method for rapid chromatography with fluid temperature and mobile phase composition control 5 2005
* 2006/0054,543 System and method for rapid chromatography with fluid temperature and mobile phase composition control 9 2005
* 2007/0077,657 Apparatuses and methods for creating and testing pre-formulations and systems for same 7 2006
 
Grifols, S.A. (1)
* 6267927 Apparatus for performing laboratory tests automatically 49 1998
 
DAKO DENMARK A/S (3)
8676509 System for tracking biological samples 8 2002
* 2003/0120,633 System for tracking biological samples 40 2002
* 2004/0266,015 Automated sample processing apparatus and a method of automated treating of samples and use of such apparatus 54 2003
 
VENTANA MEDICAL SYSTEMS, INC. (4)
7396508 Automated molecular pathology apparatus having independent slide heaters 53 2000
* 7270785 Automated molecular pathology apparatus having fixed slide platforms 33 2002
* 2004/0052,685 Automated molecular pathology apparatus having independent slide heaters 24 2003
7404927 Automated molecular pathology apparatus having fixed slide platforms 31 2005
 
ABBOTT MOLECULAR INC. (5)
* 7125722 Apparatus and method for handling fluids for analysis 2 2003
* 2004/0005,714 Apparatus and method for handling fluids for analysis 32 2003
8298498 Apparatus and method for handling fluids for analysis 0 2006
* 2006/0258,010 Apparatus and method for handling fluids for analysis 9 2006
9114392 Apparatus and method for handling fluids for analysis 0 2012
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (2)
7029922 Method for resupplying reagents in an automatic clinical analyzer 9 2003
* 2005/0014,285 Method for resupplying reagents in an automatic clinical analyzer 6 2003
 
INTERMOLECULAR, INC. (6)
6265226 Automated sampling methods for rapid characterization of polymers 78 1999
6345528 High-temperature characterization of polymers with HPLC system having multiple mobile-phase reservoirs 27 2001
6492184 Automated sampling methods with integral serial sample preparation for rapid characterization of polymers 10 2001
6584832 High-temperature characterization of polymer libraries 8 2002
6976383 Apparatus for high temperature withdrawal or dispensing of fluids 12 2003
* 2004/0025,575 High temperature characterization of fluid samples 3 2003
 
LG CHEM, LTD. (1)
* 2015/0309,063 AUTOMATIC IN VITRO DIAGNOSTIC APPARATUS INCLUDING INCLINED ROTATING PLATE 0 2013
 
APPLIED BIOSYSTEMS, LLC (1)
* 5972716 Fluorescence monitoring device with textured optical tube and method for reducing background fluorescence 45 1995
 
LJL BIOSYSTEMS, INC. (1)
* 5663545 Labware identification system 50 1995
* Cited By Examiner