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Abstract

Disclosed are methods and compositions for the diagnosis and treatment of diseases associated with aberrant expression of a somatostatin receptor (e.g., cancer) or with increased production of a factor regulatable by somatostatin (e.g., acromegaly). The compounds of the invention are of the general formulae: ##STR1## wherein P is a somatostatin peptide analog which binds to a somatostatin receptor, Y is D-tyrosine, L-tyrosine, or desamino-tyrosine, n is an integer from 1 to 32, inclusive, each q, independently, is an integer from 1 to 32, inclusive, and each s, independently, is an integer from 1 to 32, inclusive, where q and s can be the same or different, and X is of the formula D--NH.sub.2 --CH(CH.sub.2).sub.m NH.sub.2 --CO.sub.2 H or L--NH.sub.2 --CH(CH.sub.2).sub.m NH.sub.2 --CO.sub.2 H, wherein m is an integer from 1 to 10, inclusive.

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First Claim