Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
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United States of America Patent
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Jan 28, 1997
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N/A
app pub date -
Aug 25, 1994
filing date -
Aug 25, 1994
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Expired
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Abstract
Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties -A-Z-(R.sup.9).sub.n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.
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