Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
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United States of America Patent
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Feb 4, 1997
Grant Date -
N/A
app pub date -
Aug 9, 1994
filing date -
Aug 9, 1994
priority date (Note) -
Expired
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Abstract
Reversibly gel-forming compositions for sustained delivery of bio-affecting substances are disclosed. The compositions exhibit significant changes in viscosity in response to changes in pH. The compositions contain relatively low concentrations of a stable combination of at least one pH-responsive gelling polymer and at least one other thermally nonresponsive polymer. The compositions are preferably formulated to include one or more therapeutic or diagnostic agents for administration as a liquid that will gel in situ or for topical application as a pre-formed gel.
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