Oligonucleotides having phosphorothioate linkages of high chiral purity
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United States of America Patent
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Feb 4, 1997
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app pub date -
Jun 6, 1995
filing date -
Oct 15, 1991
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Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis.
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