High throughput thermal cycler

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United States of America Patent

PATENT NO 5601141
SERIAL NO

07959775

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A batch thermal cycler for large numbers of biological or chemical samples uses n modules each in good thermal contact with the samples, but substantially isolated from one another, thermally and functionally. Each module carries samples on an upper sample plate. The module has a temperature sensor adjacent the samples, an electrical resistance heating element, and a circulating fluid heat exchanger for step cooling. Heating occurs at a point generally between the samples and the source of the cooling. The modules are individually replaceable. O-rings automatically seal fluid and electrical interfaces. An electrical controller has n simultaneous channels that provide closed loop control of the electrical power to each module. As a method, the invention includes at least one modular temperature zone where the temperature is sensed at a point adjacent the samples in that zone. The samples are heated adjacent the sample plate. Cooling is by a step change. The cooling overshoots a set lower temperature. A small, well-controlled heating corrects the overshoot.

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Patent Owner(s)

Patent OwnerAddress
BROOKS AUTOMATION INC15 ELIZABETH DRIVE CHELMSFORD MA 01824

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Christopher, Anthony J Andover, MA 17 433
Gordon, Steven J Jamaica Plain, MA 24 635

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